Synthesis isolator - Isolators for HPAPI Production

Operations around chemical reactors, filters, centrifuges and dryers need to be executed under containment conditions when handling HPAPI or intermediates. Depending on process equipment dimensions, the isolator system is designed fully enclosing the equipment or only the parts where product transfer occurs.
Typical applications are:

• Reactor charging, with manual operations or drum tilting system;
• Centrifuge discharge;
• ANFD discharge, including final product packing in drums or IBC; 
• Tray dryer charging / discharging.

Production and handling of HPAPI or toxic products (in gas or powder form) need the total product separation from the environment to protect operators. Negative pressure regime is maintained within the closed volume of the isolator. Turbulent flow is generally adopted.
Operator access to isolator inside via glove ports or half-suit configuration.
Containment levels from 10µg/m3 down to 0,01µg/m3 are available, with different manufacturing solutions and configurations.
Negative pressure isolators are available for many applications:

• mechanical or fluid energy mills
• dryers 
• product synthesis
• dispensing and sampling
• formulation and packaging
• laboratory
• In Process Control
• Compounding...