Spray Congealing

Spray Congealing
Product Description

Particle Engineering Technologies
We specialize in particle engineering technologies to address oral bioavailability, lung delivery, modified release and taste masking. In each technology we can support you from proof of concept to commercial manufacturing.

Spray Congealing
In recent years the technology has been used for controlled release formulation and also for taste masking. In the latter application it is particularly suitable for oral disintegrating tablets since it provides perfect encapsulation at particle level.

How it works
The API is dissolved (or suspended) in a melted excipient (typically a low melting point polymer) and atomized into cold nitrogen leading to solidification of the droplets and particle formation. The particles are then separated from the gas stream in a cyclone and/or a filter bag. This is a solvent-free process that makes use of spray drying assets as a means of isolating the newly formed particles.

Applications
Solid dispersions
Amorphous materials (drug + polymer) used to overcome solubility limitations of BCS class 2 and 4 drugs.

Microencapsulated particles
Crystalline drug encapsulated with a coating polymer. For example, enteric polymers can be used to protect drug from the gastric conditions or for enhanced delivery to the site of maximum absorption. Similar approaches can be used for taste masking and for for protecting the drug from physical environments (e.g. light, moisture).

Pharmaceutical cocrystals
Cocrystals are multicomponent crystals of, at least, two molecules (API+coformer) combined in a stoichiometric ratio. Cocrystals have shown efficacy on improving aqueous solubility of poorly water-soluble APIs, hygroscopicity, stability, taste, and downstream processing capacity.

Hovione FarmaCiencia SA

  • PT
  • 2015
    On CPHI since
  • 2
    Certificates
  • 1000 - 4999
    Employees
Company types
Manufacturer/Innovator
Specifications
  • Supplied from
    Portugal
  • Measured In
    piece

Hovione FarmaCiencia SA

  • PT
  • 2015
    On CPHI since
  • 2
    Certificates
  • 1000 - 4999
    Employees
Company types
Manufacturer/Innovator

More Products from Hovione FarmaCiencia SA (43)

  • Everything for Inhalation

    Product Everything for Inhalation

    At Hovione we can tailor-make particle size distributions through complex particle engineering technologies, like wet-polishing and monosep, in ranges suitable for inhalation and incorporate desired morphology characteristics into your API. We are also able to start with a Hovione-produced API and develop ...
  • API PORTFOLIO

    Product API PORTFOLIO

    Hovione's APIs offer impeccable chemical purity and unique product performance.


  • OFF-PATENT APIs

    Product OFF-PATENT APIs

    High value applications Hovione provides off-patent APIs that can be used with confidence where the choice of active ingredient is critical.
    • Branded generics where quality and security of supply is paramount • Difficult to make AB rated generics such as nasal and inhalation products where devel...
  • Hot Melt Extrusion

    Product Hot Melt Extrusion

    Hot melt extrusion is a fast growing technology platform that is utilized to solve difficult formulation challenges, primarily in the area of solubilization.
    n recent years Hot Melt Extrusion (HME) has been used extensively in solubility enhancement applications for polymer-based amorphous solid dispe...
  • Jet Milling

    Product Jet Milling

    Particle Engineering Technologies We specialize in particle engineering technologies to address oral bioavailability, lung delivery, modified release and taste masking. In each technology we can support you from proof of concept to commercial manufacturing.
    Jet milling
    Jet milling is a highl...
  • Nanoparticles

    Product Nanoparticles

    Particle Engineering Technologies
    We specialize in particle engineering technologies to address oral bioavailability, lung delivery, modified release and taste masking. In each technology we can support you from proof of concept to commercial manufacturing.

    Nanoparticles
    At Hovione we ...
  • Wet Polishing

    Product Wet Polishing

    Particle Engineering Technologies
    We specialize in particle engineering technologies to address oral bioavailability, lung delivery, modified release and taste masking. In each technology we can support you from proof of concept to commercial manufacturing.
    Wet Polishing
    Hovione developed ...
  • Aclidinium Bromide

    Product Aclidinium Bromide

    Aclidinium Bromide for development trials with customized Particle Design, resulting in Inhalation grade material with highly customizable PSD to befit your application.
    Our technology and expertise yields unmatched impurity profiles with highly reproducibility between batches, resulting in ...
  • Beclomethasone Dipropionate Anhydrous

    Product Beclomethasone Dipropionate Anhydrous

    ROUTE OF ADMINISTRATION: Inhalation, Nasal, Oral, Topical
    Hovione is a world leader in regulated markets offering APIs for human applications for over 60 years.
    With an unblemished regulatory track record Hovione makes available offer an unrivalled technological range to provide the API with...
  • Beclomethasone Dipropionate Monohydrate

    Product Beclomethasone Dipropionate Monohydrate

    Hovione has over 57 years of experience in the manufacture of corticosteroids with uncompromising quality and an unblemished Regulatory track record.
    With an unrivalled range of particle size reduction technologies for the production of tailor made API, featuring a near-perfect particle size dist...
  • Betamethasone Acetate

    Product Betamethasone Acetate

    Hovione has over 57 years of experience in the manufacture of corticosteroids. Injectable quality available on demand from the European producer with an unblemished Regulatory track record.
    Approved branded and generic human applications.
    Sterile material to be avai...
  • Betamethasone Disodium Phosphate

    Product Betamethasone Disodium Phosphate

    Corticosteroid ROUTE OF ADMINISTRATION: Ophthalmic, Injectable, TopicalREGULATORY STATUS: US DMF, JP DMF

Hovione FarmaCiencia SA resources (5)