Nanoparticles

Particle Engineering Technologies
We specialize in particle engineering technologies to address oral bioavailability, lung delivery, modified release and taste masking. In each technology we can support you from proof of concept to commercial manufacturing.

Nanoparticles
At Hovione we have both top-down and bottom-up technologies to produce pharmaceutical nanoparticles for oral delivery.


Nanoparticles are very useful when oral bioavailability is limited by the dissolution rate of the active pharmaceutical ingredient. The commercial utility is expressed by the multiple products approved in the market over the last decades. Hovione particle design tool box includes both “Top Down” and “Bottom up” technologies to produce nanoparticles of active ingredients.

How it works
In top down processes, nanoparticles are produced by wet milling processes. On the other hand, in bottom up processes crystalline or amorphous nanoparticles can be obtained by crystallization or precipitation processes, respectively. Nanoparticle isolation or microencapsulation can then be achieved by spray drying.

Applications

Overcome solubility limitations of BCS class 2 and 4 drugs - oral administration as capsules, tablets or suspensions
Sustained release formulations e.g. in ocular delivery
Injectable formulations