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5 Oct 2016

Pall Life Sciences launches the Cadence BioSMB Process system

Enables fully scalable, continuous multicolumn chromatography

Pall Life Sciences has launched the Cadence BioSMB Process system single-use flow path, continuous multicolumn chromatography. It has been designed for linear scale-up of an existing PD-scale continuous purification process to a GMP-compliant process-scale continuous purification using feedstreams derived from fed batch bioreactors of up to 2,000-L.

The Cadence BioSMB Process system can operate with up to eight chromatography columns. It features integrated single-use pump heads, a valve cassette, sensors and flow path to support various chromatographic steps, while also reducing cleaning validation needs. Furthermore, the open platform of the system allows for the use of multiple chromatographic technologies. Ultimately, the chromatographic sorbents are used more efficiently, resulting in smaller column volumes and improved process economics.

“The Cadence BioSMB Process system follows on from the launch of our Cadence BioSMB Process Development (PD) system this Spring, fulfilling the commitment our team made last year to enabling seamless purification from PD to process scale,” said Michael Egholm, VP and general manager of biopharmaceuticals at Pall Life Sciences. “Users can scale their process without changing process parameters, buffers or sorbents, which saves time and money.”

In line with Pall Life Sciences' drive to continuously improve bioprocesses, the Cadence BioSMB Process system is designed for integration with other Pall products to enable integration of continuous downstream solutions.

The Cadence BioSMB Process system will be on display at BPI 2016 in Boston, MA from 4-7 October in booth 521.

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