Compact granulation system

The First Ever Truly Continuous Twinscrew Granulator and Dryer Challenges in Continuous Wet Granulation and Drying: • THE L.B. Bohle QbCon® 1 is the ideal device for the introduction of continuous wet granulation in the pharmaceutical industry • No continuous fluid-bed dryer on the market that is s...

L. B. Bohle Gmbh offers a wide range of process machines which includes bohle tablet coater btc. It is the most economical alternative for all common coating applications. Benefits: it provides homogeneous mixing due to patented spirals, the gentle mechanical treatment of tablet cores to avoid edging and b...

L. B. Bohle Gmbh offers a wide range of process machines which includes compactor brc 25 and brc 100. Benefits: minimal material loss due to precise control of the compression force with an innovative electromechanical roller drive, constant ribbon properties assured with sensitive gap width control and ea...

L. B. Bohle Gmbh offers a wide range of process machines which includes vma - single pot granulator for pharmaceutical applications. It is a granulating and drying system specifically optimized for pharmaceutical applications. The flexible machine is state-of-the-art, and exceeds current gmp requirements w...

L. B. Bohle Gmbh offers a wide range of process machines which includes bohle fluid bed system bfs - bohle uni cone buc ®. It is the productive, practical and precise alternative to conventional wurster processing. it features a broad range of extension options for bottom tangential spray granulation as we...

L. B. Bohle Gmbh offers a wide range of process machines which includes bohle film coater bfc. Benefits: it provides homogeneous mixing due to patented spirals, simple and quick discharging by reversing the direction of rotation and has a high sophisticated control system. Contact us for more information.

Bohle is the world’s leading manufacturer of blenders. The high efficiency of the Bohle blending systems is based on the revolutionary and patented counter-current process principle.

The range of Bohle blending systems shows the flexibility of our engineering and manufacturing departments. B...

L. B. Bohle Gmbh offers a wide range of process machines which includes bohle film coater bfc tripan. It is a bohle film coater with a suspension supply via a single pump head. tripan can be operated with three pans for batch sizes of 7 to 75 liters. Benefits: it provides easy cleaning, has a suspension su...

L. B. Bohle Gmbh offers a wide range of process machines which includes koco® - the first semi-continuous coater. Benefits: the ease-of-use and the high coating quality of the tablets and the innovative nozzle arrangement significantly reduces spray loss as well as suspension application. Contact us for mo...

The Granumator ® GMA is a granultion system specifically optimized for pharmaceutical applications. The impeller is designed for high shear and compression, ensuring effective granulation. The chopper prevents excessive granule growth and distributes the granulating liquid within the product.
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L. B. Bohle Gmbh offers a wide range of process machines which includes bohle film coater bfc 5 - stand-alone unit. It is is a stand-alone unit. The entire air technique as well as electrical and control technique is integrated in the system. Benefits: it can be operated with one of two differtent pan size...

The Bohle Tablet Checker is used for a mechanical check of the thickness of sugar-coated or film-coated pills, capsules and tablets. The feeding hopper is filled with tablets to be tested. From there, a vibrator system guides the tablets to the rotating sorting discs.

Three different gro...

Continuous wet granulation and drying have long been a hot topic in pharmaceutical research and development (R&D) and industry. However, there is no truly continuous fluid-bed dryer on the market that is suitable for a long process time and that meets the quality requirements described in the present article. This article outlines the experimental testing on a new R&D system (QbCon® 1) for truly continuous granulation and drying. Special attention is paid to the dryer and the resulting granules.
The results show that very narrow and reproducible residence time distributions are achieved in the dryer, which leads to uniform drying of the granules of different size classes. The process delivers consistent quality regarding moisture and particle size of the granules over several hours. When changing the conveying speed of the granules in the dryer while maintaining all other parameters, it was possible to describe the limits for a fixed process/formulation combination, ...

Learn more about our comprehensive equipment which enables the production of tablets from powder to the coated tabet via batch and continuous processing.

L.B. Bohle has been the technological leader for all film coating applications for more than 15 years. Bohle Coaters guarantee excellent product processing with the highest profitability. We assert our leading role through continuous developments and patented advantages. Pharmaceutical Tablet Coating Processes Can be Divided into Three Basic Operations: MixingSprayingDrying Each step is carefully engineered and optimized to coordinate with the others. Bohle Coaters offer the best combination of the processing operations on the market.

Fluid bed equipment has been well known and established in the pharmaceutical industry for many years. Using a tangential fluid bed system represents state of the art technology in pharmaceutical manufacturing for particle coating, granulation and drying. With this in mind L.B. Bohle developed the Bohle Fluid Bed Systems with tangentially mounted spray nozzles and the Bohle Uni Cone BUC®.

The pharmaceutical production of tablets is practically unthinkable without the use of a sieve or a mill. These are needed whenever active and inactive materials are handled and tablets or other products are being manufactured. Sieving machines and mills are used for milling solids to reduce their size. This fulfils two purposes: Firstly, it enlarges the particle surface which increases the speed of dissolution. Secondly, it evens out differences between particle sizes to ensure that mixing can be homogeneous.  Due to their versatility, milling and sieving machines play a crucial role in pharmaceutical production. They can be integrated into complex production lines, for example for filling/emptying or transfer operations at process machines, or for filling and decanting containers.

In the pharmaceutical industry, one term is becoming increasingly important: containment. It describes the process of containing a substance within a defined space, a method that is suitable for protecting operators and the environment in case of high toxicity and product reactivity. At the same time, containment prevents dust, gases or vapours from being released into the environment and contaminating the product.