QbCon 1

QbCon 1
Product Description

The First Ever Truly Continuous Twinscrew Granulator and Dryer Challenges in Continuous Wet Granulation and Drying:

  • THE L.B. Bohle QbCon® 1 is the ideal device for the introduction of continuous wet granulation in the pharmaceutical industry
  • No continuous fluid-bed dryer on the market that is suitable for long process times and meets all quality requirements.
  Our Solution for Your Continuous Wet Granulation and Drying: THE L.B. Bohle QbCon® 1 is the ideal device for the introduction of continuous wet granulation
  • QbCon® 1 achieves truly continuous drying and granulation for the first time with very narrow and reproducible residence time distributions in the dryer.  It also maintains a stable quality of the granules with regard of moisture and particle size.
  • QbCon® 1 is a system with fully-integrated software and unit operations consisting of different components by L.B. Bohle (liquid feeding, wet granulation, drying, automatization) and Gericke AG (powder feeding).
  • By use of PAT it is possible to monitor the production process inline. This leads to constant production of high-quality products, high patient safety, lower costs, better process understanding and optimized process control.
  • The entire process is controlled and monitored via a touch panel.
  • The design of QbCon® 1 is very space-saving, and the nominal throughput of the system is 0.5-4 kg/h, but can significantly deviate upwards.
  QbCon® 1 – Revolutionary system for your R&D and an ideal device for the introduction of  continuous wet granulation!

L.B. Bohle Maschinen und Verfahren GmbH

  • DE
  • 2015
    On CPHI since
  • 1
    Certificates
  • 250 - 499
    Employees
Company types
Machinery and Equipment Supplier/Manufacturer
Specifications

L.B. Bohle Maschinen und Verfahren GmbH

  • DE
  • 2015
    On CPHI since
  • 1
    Certificates
  • 250 - 499
    Employees
Company types
Machinery and Equipment Supplier/Manufacturer

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L.B. Bohle Maschinen und Verfahren GmbH resources (1)

  • Whitepaper QbCon® 1 combines the three continuous processes of raw material dosing, twin-screw wet granulation and drying.

    Continuous wet granulation and drying have long been a hot topic in pharmaceutical research and development (R&D) and industry. However, there is no truly continuous fluid-bed dryer on the market that is suitable for a long process time and that meets the quality requirements described in the present article. This article outlines the experimental testing on a new R&D system (QbCon® 1) for truly continuous granulation and drying. Special attention is paid to the dryer and the resulting granules.
    The results show that very narrow and reproducible residence time distributions are achieved in the dryer, which leads to uniform drying of the granules of different size classes. The process delivers consistent quality regarding moisture and particle size of the granules over several hours. When changing the conveying speed of the granules in the dryer while maintaining all other parameters, it was possible to describe the limits for a fixed process/formulation combination, ...