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Plant Debottlenecking by Continuous Manufacturing Case Study

Plant Debottlenecking by Continuous Manufacturing Case Study
Product Description

Debottlenecking through Continuous Production Capacity increase by means of small skids in the batch plantContinuous production will help you solve the bottlenecks you are currently facing with batch production. The advantages of continuous production are countless, but we have summarized and illustrated them for you to help you make the switch from batch to continuous production!

Microinnova Engineering GmbH

  • AT
  • 2015
    On CPHI since
  • 5
    Certificates
  • 25 - 49
    Employees
Company types
Academic/Research
Contract Research Organisation (CRO)
Engineering
Machinery and Equipment Supplier/Manufacturer
Primary activities
Chemical Development
Contract Research Organisation
Laboratory Services
Laboratory, Analytical, Biotechnology Equipment
Supply Chain
Technology

Microinnova Engineering GmbH

  • AT
  • 2015
    On CPHI since
  • 5
    Certificates
  • 25 - 49
    Employees
Company types
Academic/Research
Contract Research Organisation (CRO)
Engineering
Machinery and Equipment Supplier/Manufacturer
Primary activities
Chemical Development
Contract Research Organisation
Laboratory Services
Laboratory, Analytical, Biotechnology Equipment
Supply Chain
Technology

More Products from Microinnova Engineering GmbH (8)

  • Continuous Manufacturing API Plant

    Product Continuous Manufacturing API Plant

    Continuous Manufacturing API Plant
  • Engineering Services for Continuous Manufacturing and for Modular Plants

    Product Engineering Services for Continuous Manufacturing and for Modular Plants

    Basic Engineering - Transform your optimized process into manufacturingMICROINNOVA's engineering team is turning developed continuous chemical laboratory processes into your desired manufacturing plants. Starting with first steps such as piping and instrumentation diagrams (P&ID) and a U...
  • Flow Miniplant

    Product Flow Miniplant

    Bench-top pilot plant for development and small-scale production. The Flow Miniplant is Microinnova’s bench-top flow pilot-plant for the production of quantities between 1 and 100 litres per hour. It bridges the gap between lab-scale flow process development and bulk manufacturing. It’s an indispensable st...
  • GMP Modular Continuos Manufacturing API Plant with Solids

    Product GMP Modular Continuos Manufacturing API Plant with Solids

    We specialize in process development and the design of modular plants and have developed an excellent concept for it. We provide the whole package. From process design, over cost evaluation, to your turnkey plant, optimized and tailored to suit your specific needs. The implementation of a modular...
  • Modular Continuous Manufacturing Crystallization Plant

    Product Modular Continuous Manufacturing Crystallization Plant

    Modular multi-purpose API crytallization plant with PAT and module predictive control.
  • Overview Products and Services Continuous Manufacturing

    Product Overview Products and Services Continuous Manufacturing

    PROCESS RESEARCH 

    Development of efficient synthesis routes using the advantages of continuous processing. 

    PROCESS DESIGN

    Decades of experience in process intensification, flow chemistry and continuous processing gives us the ability to investigate the best appro...
  • Continuous Manufacturing of Formulations in Minutes Instead of Hours

    Product Continuous Manufacturing of Formulations in Minutes Instead of Hours

    Microinnova Engineering GmbH has successfully commissioned two continuous formulation production plants for a European client. The design of the fully automated plant is very compact, which makes it possible to easily transport & install it at a different manufacturing site on the other side of the wor...
  • FlowKiloLab

    Product FlowKiloLab

    Modular plants accelerate time-to-market by using the same infrastructure for development and manufacturing. Production capacities adjust quickly, enabling faster product launches without long construction times. The use of scalable equipment enables a fast scaleup.

    Module Type Package Proto...

Microinnova Engineering GmbH resources (23)

  • Sponsored Content Capacity Boost by Batch-to-Conti Debottlenecking

    Space economy is a typical issue for debottlenecking projects. Since a continuous approach reduces mass and heat transfer distances up to a factor of 100, these solutions can easily be integrated into an existing batch environment. 


     
  • Brochure Who is Microinnova?

    A short presentation highlighting our expertise!
  • Sponsored Content Modular Plants: Speed as the Key Success Factor for Chemical Businesses in the Future

    We expect that speed and flexibility will be success factors for chemical businesses in the future. 
  • Brochure Microinnova Chemistry Portfolio

    PROCESS RESEARCH 

    Development of efficient synthesis routes using the advantages of continuous processing. 

    PROCESS DESIGN

    Decades of experience in process intensification, flow chemistry and continuous processing gives us the ability to investigate the best approach and strategy to put your process into an efficient system.

    CHEMICAL AND TECHNICAL FEASIBILITY

    Inside our flow lab scale plants we have multiple technologies available to develop continuous experimental procedures with the principal objective of showing a reliable mode of operation.

    OPTIMIZATION & PILOT PHASE

    Depending on the inherent characteristics each verified continuous process is optimized. The optimal processing window is determined on scalable equipment to finally deliver a robust continuous system.

  • Sponsored Content Corning and Microinnova Celebrate Opening of Advanced-Flow™ Reactor Qualified Lab

    Corning Incorporated and Microinnova recently celebrated the opening of the Corning® Advanced-Flow™ Reactors (AFR) Application Qualified Lab (AQL) at their facility near Graz. Application qualified labs enable AFR customers to effectively access continuous-flow demonstrations, experimental trials, feasibility testing, and chemical reaction process development.

     
  • Video Modular Plants for Smart Manufacturing

    My name is Katharina and I will show you how continuous modular plants will change chemical processing for a more sustainable future, using modular plug & play plants. We see some issues with batch processing. Sometimes there are concentration spots, the walls are too hot for the molecules. Our philosophy is that all molecules should have the same processing conditions. This we realize by looking at the critical parameters of the chemistry and selecting the right process intensification technology. Furthermore, the space-time-yield can be maximized by a magnitude or more by reducing mass and heat transfer distances, leading to much shorter residence times and compact designs. Since we already have a continuous operating plant in the lab, scale-up becomes much easier. Continuous manufacturing allows for superior quality control due to advanced PAT. Standardized modules enable a quick realization of reduced time to produce and time-to-market. More infos below video!
  • Sponsored Content Intensification Boost for Enzymatic Liquid/Gas Processes by means of Continuous Flow Processing

    O2-dependent biotransformation reactions have proven difficult in fine chemical manufacturing due to the mass transfer limitations of supplying O2 to the enzymatic reaction, hence affecting the level of efficiency achieved. 
     
  • Video 8 Differentiators that make Microinnova Unique

    Microinnova serves its customers as a one-stop-shop from development to manufacturing plants. The following eight differentiators make Microinnova unique. 1. Microinnova focuses on end-to-end continuous manufacturing, dealing with processes in the area of synthesis, work-up and formulation. 
    2. We work with a wide range of different process intensification technologies. We select the best technology for each process. We want to enable uniform process conditions for each molecule. 
    3. We are used to working in regulated environments. We are DIN EN ISO 9001 certified. We can build plants that fulfill typical standards for regulated environments like GMP and ATEX. 
    4. We can handle various conditions. We can process highly viscous materials like melts, suspensions, precipitates and solids in packed or trickle beds. 


    Our other 4 differentiators you can find in the video!
  • Sponsored Content Microinnova Sponsors Award for Outstanding Process Intensification Work Towards CO2 Reduction

    We were honored to have the opportunity to sponsor the 2021 EFCE Excellence Award in Process Intensification.
     
  • Brochure 2nd Generation API Synthesis

    Continuous Manufacturing with Half of the Unit Operations
  • Sponsored Content Microinnova strengthens the field of Digital Processing using Digital Twin Model

    Microinnova strengthens the field of Digital Processing by kicking off the Project “PharmComplete” using Digital Twin, Model-Predictive-Control and PAT strategies.
  • Brochure Process Development & Plant Concept

    ...for a Continuous Hydrogenation Plant

    Environmental & Economic Impact of Solvent-Free Continuous API Manufacture of a Rufinamide Precursor
  • Brochure Flexible Continuous Production

    A continuously operated plant with 4 functional modules was delivered to Evonik Industries in Germany. The plant incorporates advances in process performance and modular "plug-and-play“chemical production technology.
  • Brochure Continuous Modular Crystallization Plants

    Microinnova delivered two modular continuous crystallization plants to the research center CMAC in Scotland and one continuous crystallization plant with an integrated filter-dryer unit to the University of Sheffield. Continuous crystallization, filtration and drying, as an integrated system during continuous manufacturing, is one of the most challenging topics in downstream processing.
  • Brochure Performance Boost for Enzymatic Oxidations by Means of Process Intensification & Continuous Manufacturing

    O₂-dependent biotransformations are promising for chemical synthesis. Their development to the level of efficiency required in fine chemical manufacturing has proven difficult, however, due to thermodynamic and kinetic limitations when supplying O₂ to the enzymatic reaction creating a complex bottleneck on conversion efficiency using batch technology at atmospheric pressure.
  • Brochure In-Situ Bromine Generation for Photochemical Applications in Continuous Manufacturing

    Continuous manufacturing enables options to generate and use hazardous or unstable reagents in a safe manner on manufacturing scale. In this study, we present how in-situ generated bromine can be used for a photochemical application.
  • Brochure 2nd Generation API Synthesis

    Continuous manufacturing with half of the unit operations.
  • Brochure Process Development & Plant Concept

    ...for a continuous hydrogenation plant.
  • Brochure Continuous Modular Crystallization Plants

    Microinnova delivered two modular continuous crystallization plants to the research center CMAC in Scotland and one continuous crystallization plant with an integrated filter-dryer unit to the University of Sheffield. Continuous crystallization, filtration and drying, as an integrated system during continuous manufacturing, is one of the most challenging topics in downstream processing.
  • Brochure Flexible Continuous Production

    A continuously operated plant with 4 functional modules was delivered to Evonik Industries in Germany. The plant incorporates advances in process performance and modular "plug-and-play“ chemical production technology.
  • Brochure Continuous Manufacturing Modular API Plant

    CordenPharma commissioned a modular continuous manufacturing plant from Microinnova Engineering, facilitating improved production capacity.
  • Brochure Debottlenecking by Continuous Production

    Capacity increase by means of small skids in the batch plant

    Continuous production will help you solve the bottlenecks you are currently facing with batch production. The advantages of continuous production are countless, but we have summarized and illustrated them for you to help you make the switch from batch to continuous production!
  • Brochure Continuous Manufacturing of Formulations in Minutes instead of Hours

    Microinnova Engineering GmbH has successfully commissioned two continuous formulation production plants to a European client. The design of the fully automated plant is very compact, which makes it possible to easily transport & install it at a different manufacturing site on the other side of the world.  It possesses an integrated Plug & Play concept, which means that 14 tons per day can be produced. All streams are controlled with precise mass flow meters so no labor intensive pre-weight of substances is needed and instant change of recipe is possible. This provides an easy capacity increase for the client and enables the production of new products.“ 

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