Flexible Continuous Production

Space economy is a typical issue for debottlenecking projects. Since a continuous approach reduces mass and heat transfer distances up to a factor of 100, these solutions can easily be integrated into an existing batch environment. 


 

A short presentation highlighting our expertise!

We expect that speed and flexibility will be success factors for chemical businesses in the future. 

PROCESS RESEARCH 

Development of efficient synthesis routes using the advantages of continuous processing. 

PROCESS DESIGN

Decades of experience in process intensification, flow chemistry and continuous processing gives us the ability to investigate the best approach and strategy to put your process into an efficient system.

CHEMICAL AND TECHNICAL FEASIBILITY

Inside our flow lab scale plants we have multiple technologies available to develop continuous experimental procedures with the principal objective of showing a reliable mode of operation.

OPTIMIZATION & PILOT PHASE

Depending on the inherent characteristics each verified continuous process is optimized. The optimal processing window is determined on scalable equipment to finally deliver a robust continuous system.

Corning Incorporated and Microinnova recently celebrated the opening of the Corning® Advanced-Flow™ Reactors (AFR) Application Qualified Lab (AQL) at their facility near Graz. Application qualified labs enable AFR customers to effectively access continuous-flow demonstrations, experimental trials, feasibility testing, and chemical reaction process development.

 

My name is Katharina and I will show you how continuous modular plants will change chemical processing for a more sustainable future, using modular plug & play plants. We see some issues with batch processing. Sometimes there are concentration spots, the walls are too hot for the molecules. Our philosophy is that all molecules should have the same processing conditions. This we realize by looking at the critical parameters of the chemistry and selecting the right process intensification technology. Furthermore, the space-time-yield can be maximized by a magnitude or more by reducing mass and heat transfer distances, leading to much shorter residence times and compact designs. Since we already have a continuous operating plant in the lab, scale-up becomes much easier. Continuous manufacturing allows for superior quality control due to advanced PAT. Standardized modules enable a quick realization of reduced time to produce and time-to-market. More infos below video!

O2-dependent biotransformation reactions have proven difficult in fine chemical manufacturing due to the mass transfer limitations of supplying O2 to the enzymatic reaction, hence affecting the level of efficiency achieved. 
 

Microinnova serves its customers as a one-stop-shop from development to manufacturing plants. The following eight differentiators make Microinnova unique. 1. Microinnova focuses on end-to-end continuous manufacturing, dealing with processes in the area of synthesis, work-up and formulation. 
2. We work with a wide range of different process intensification technologies. We select the best technology for each process. We want to enable uniform process conditions for each molecule. 
3. We are used to working in regulated environments. We are DIN EN ISO 9001 certified. We can build plants that fulfill typical standards for regulated environments like GMP and ATEX. 
4. We can handle various conditions. We can process highly viscous materials like melts, suspensions, precipitates and solids in packed or trickle beds. 


Our other 4 differentiators you can find in the video!

We were honored to have the opportunity to sponsor the 2021 EFCE Excellence Award in Process Intensification.
 

Continuous Manufacturing with Half of the Unit Operations

Microinnova strengthens the field of Digital Processing by kicking off the Project “PharmComplete” using Digital Twin, Model-Predictive-Control and PAT strategies.

...for a Continuous Hydrogenation Plant

Environmental & Economic Impact of Solvent-Free Continuous API Manufacture of a Rufinamide Precursor

Microinnova delivered two modular continuous crystallization plants to the research center CMAC in Scotland and one continuous crystallization plant with an integrated filter-dryer unit to the University of Sheffield. Continuous crystallization, filtration and drying, as an integrated system during continuous manufacturing, is one of the most challenging topics in downstream processing.

O₂-dependent biotransformations are promising for chemical synthesis. Their development to the level of efficiency required in fine chemical manufacturing has proven difficult, however, due to thermodynamic and kinetic limitations when supplying O₂ to the enzymatic reaction creating a complex bottleneck on conversion efficiency using batch technology at atmospheric pressure.

Continuous manufacturing enables options to generate and use hazardous or unstable reagents in a safe manner on manufacturing scale. In this study, we present how in-situ generated bromine can be used for a photochemical application.

Continuous manufacturing with half of the unit operations.

...for a continuous hydrogenation plant.

Microinnova delivered two modular continuous crystallization plants to the research center CMAC in Scotland and one continuous crystallization plant with an integrated filter-dryer unit to the University of Sheffield. Continuous crystallization, filtration and drying, as an integrated system during continuous manufacturing, is one of the most challenging topics in downstream processing.

A continuously operated plant with 4 functional modules was delivered to Evonik Industries in Germany. The plant incorporates advances in process performance and modular "plug-and-play“ chemical production technology.

CordenPharma commissioned a modular continuous manufacturing plant from Microinnova Engineering, facilitating improved production capacity.

Capacity increase by means of small skids in the batch plant

Continuous production will help you solve the bottlenecks you are currently facing with batch production. The advantages of continuous production are countless, but we have summarized and illustrated them for you to help you make the switch from batch to continuous production!

Microinnova Engineering GmbH has successfully commissioned two continuous formulation production plants to a European client. The design of the fully automated plant is very compact, which makes it possible to easily transport & install it at a different manufacturing site on the other side of the world.  It possesses an integrated Plug & Play concept, which means that 14 tons per day can be produced. All streams are controlled with precise mass flow meters so no labor intensive pre-weight of substances is needed and instant change of recipe is possible. This provides an easy capacity increase for the client and enables the production of new products.“