Genomics & Proteomics (Biopharmaceutical Services)

Identify linear or conformational epitopes with amino acid resolution. Based on high-density peptide microarrays with linear or cyclic constrained peptides for conformational analyses, our PEPperMAP® Epitope Mapping Services enable the fingerprint analysis of antibody epitopes. Underlined by more than 2...

Antibodies are essential tools for therapeutic, diagnostic and research purposes. However, they are often poorly characterized in terms of specificity and cross-reactivity. PEPperPRINT offers various solutions for target discovery and the profiling of off-target interactions against tens of thousands o...

We validate the binding specificity of your antibody by an all-in-one analysis package including a high-resolution PEPperMAP® Epitope Mapping, a subsequent PEPperMAP® Epitope Substitution Scan to identify conserved and variable amino acid positions and a PEPperMAP® Antibody Cross-Reactivity Profiling....

From single antigens to whole proteomes converted into overlapping peptides, or covering any epitope, peptide or antigen collection – PEPperCHIP® Custom Peptide Microarrays can be fully tailored in a uniquely fast and cost-effective manner with up to 25,000 peptides per glass slide – including non-natur...

PEPperCHIP® Peptide Microarrays enable you to investigate protein-protein interactions by high resolution peptide mapping with linear or cyclic constrained peptides for conformational binding motifs. Analyze up to 25,000 different peptides in a single assay including various post-translational modifica...

High density PEPperCHIP® Peptide Microarrays with up to 25,000 linear or cyclic constrained peptides allow for the discovery, validation and engineering of peptide therapeutics or protein ligands. PEPperMAP® Peptide Discovery can incorporate full D-peptides, N-methylated or phosphorylated amino acids, ...

Understand T cell-mediated responses and discover the full potential of your immunological innovation, be it a vaccination strategy or cutting-edge immunotherapy solution. In response to antigen-specific stimulation, different subtypes of T cells release characteristic cytokines (IFN-γ, TNF-α, IL-4 etc...

Regulatory T cells (Tregs) are promising cellular targets for the treatment of cancer and autoimmune diseases. We provide the quantitative analysis of the phenotype of Tregs by antibody staining of Treg-specific markers and flow cytometry. PEPperPRINT offers iTreg polarization assay and iTreg suppressi...

T cells are activated upon contact with other cells that present an appropriate peptide-MHC complex. The immunogenicity of the peptides is thereby restricted by their binding motives to different MHC proteins among individuals. At PEPperPRINT, we set up a peptide library by converting the original prot...

B cells and T cells can respond cooperatively to the same antigen, and in some cases a B cell epitope may simultaneously function as T cell epitope. To identify coincident T cell and B cell epitopes, serum samples are screened with PEPperCHIP® Peptide Microarrays for B cell receptor epitopes, and hit p...

Protein or antibody drug immunogenicity results in the generation of anti-drug antibodies (ADAs), which can reduce drug efficacy, neutralize therapeutic effects or even cause severe immune adverse events to the patient. We provide the fingerprint analysis of anti-drug antibody responses on the epitope ...

Monitor pre-existing and drug-related antibody and T cell responses for immune adverse effect risk assessment. We provide the fingerprint immunogenicity analysis of your antibody or protein drug in a single assay with epitope mapping technology, including T cell services to determine the presence of mA...