Fingerprint Analysis of Immune Adverse Effects

Fingerprint Analysis of Immune Adverse Effects
Product Description

Monitor pre-existing and drug-related antibody and T cell responses for immune adverse effect risk assessment. We provide the fingerprint immunogenicity analysis of your antibody or protein drug in a single assay with epitope mapping technology, including T cell services to determine the presence of mAb-reactive T cells in patient PBMCs by ELISpot. This dual strategy enables comparison of the immune landscape among patients with and without adverse effects.

PEPperPRINT GmbH

  • DE
  • 2023
    On CPHI since
  • 1
    Certificates
  • 25 - 49
    Employees
Company types
Manufacturer/Innovator
Primary activities
Custom Manufacturing/Custom Synthesis
Specifications
  • Selling Points
    Experienced Technicians; Product Features; Quality Service; Reputation; PEPperPRINT’s peptide microarrays and screening services have been used by researchers around the world with over 250 peer-reviewed publications.
  • Supplied from
    Germany

PEPperPRINT GmbH

  • DE
  • 2023
    On CPHI since
  • 1
    Certificates
  • 25 - 49
    Employees
Company types
Manufacturer/Innovator
Primary activities
Custom Manufacturing/Custom Synthesis

More Products from PEPperPRINT GmbH (11)

  • PEPperMAP® Epitope Mapping

    Product PEPperMAP® Epitope Mapping

    Identify linear or conformational epitopes with amino acid resolution. Based on high-density peptide microarrays with linear or cyclic constrained peptides for conformational analyses, our PEPperMAP® Epitope Mapping Services enable the fingerprint analysis of antibody epitopes. Underlined by more than 2...
  • Anti-Drug Antibody Analysis

    Product Anti-Drug Antibody Analysis

    Protein or antibody drug immunogenicity results in the generation of anti-drug antibodies (ADAs), which can reduce drug efficacy, neutralize therapeutic effects or even cause severe immune adverse events to the patient. We provide the fingerprint analysis of anti-drug antibody responses on the epitope ...
  • PEPperCHIP® High-Density Peptide Microarrays

    Product PEPperCHIP® High-Density Peptide Microarrays

    From single antigens to whole proteomes converted into overlapping peptides, or covering any epitope, peptide or antigen collection – PEPperCHIP® Custom Peptide Microarrays can be fully tailored in a uniquely fast and cost-effective manner with up to 25,000 peptides per glass slide – including non-natur...
  • Combined B and T Cell Epitope Mapping

    Product Combined B and T Cell Epitope Mapping

    B cells and T cells can respond cooperatively to the same antigen, and in some cases a B cell epitope may simultaneously function as T cell epitope. To identify coincident T cell and B cell epitopes, serum samples are screened with PEPperCHIP® Peptide Microarrays for B cell receptor epitopes, and hit p...
  • Regulatory T Cell Characterization

    Product Regulatory T Cell Characterization

    Regulatory T cells (Tregs) are promising cellular targets for the treatment of cancer and autoimmune diseases. We provide the quantitative analysis of the phenotype of Tregs by antibody staining of Treg-specific markers and flow cytometry. PEPperPRINT offers iTreg polarization assay and iTreg suppressi...
  • T Cell Epitope Mapping

    Product T Cell Epitope Mapping

    T cells are activated upon contact with other cells that present an appropriate peptide-MHC complex. The immunogenicity of the peptides is thereby restricted by their binding motives to different MHC proteins among individuals. At PEPperPRINT, we set up a peptide library by converting the original prot...
  • T Cell Immune Monitoring

    Product T Cell Immune Monitoring

    Understand T cell-mediated responses and discover the full potential of your immunological innovation, be it a vaccination strategy or cutting-edge immunotherapy solution. In response to antigen-specific stimulation, different subtypes of T cells release characteristic cytokines (IFN-γ, TNF-α, IL-4 etc...
  • PEPperMAP® Antibody Validation

    Product PEPperMAP® Antibody Validation

    We validate the binding specificity of your antibody by an all-in-one analysis package including a high-resolution PEPperMAP® Epitope Mapping, a subsequent PEPperMAP® Epitope Substitution Scan to identify conserved and variable amino acid positions and a PEPperMAP® Antibody Cross-Reactivity Profiling....
  • PEPperMAP® Antibody Cross-Reactivity Profiling

    Product PEPperMAP® Antibody Cross-Reactivity Profiling

    Antibodies are essential tools for therapeutic, diagnostic and research purposes. However, they are often poorly characterized in terms of specificity and cross-reactivity. PEPperPRINT offers various solutions for target discovery and the profiling of off-target interactions against tens of thousands o...
  • PEPperMAP® Peptide Discovery

    Product PEPperMAP® Peptide Discovery

    High density PEPperCHIP® Peptide Microarrays with up to 25,000 linear or cyclic constrained peptides allow for the discovery, validation and engineering of peptide therapeutics or protein ligands. PEPperMAP® Peptide Discovery can incorporate full D-peptides, N-methylated or phosphorylated amino acids, ...
  • PEPperMAP® Protein Interaction Analysis

    Product PEPperMAP® Protein Interaction Analysis

    PEPperCHIP® Peptide Microarrays enable you to investigate protein-protein interactions by high resolution peptide mapping with linear or cyclic constrained peptides for conformational binding motifs. Analyze up to 25,000 different peptides in a single assay including various post-translational modifica...

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