Carbidopa

(Arg8)-Vasopressin or argipressin is an antidiuretic peptide hormone that plays a key role in maintaining plasma osmolality. The peptide released from the posterior pituitary gland promotes renal tubular reabsorption of water. Argipressin is involved in the control of circadian rhythm, thermoregulation, an...

Icatibant Acetate is a selective competitive antagonist for the bradykinin B2 receptor. It is indicated for the treatment of acute attacks of hereditary angioedema (HAE). HAE is a rare disorder resulting in periodic attacks of acute edema. It is characterized by a deficiency of functional C1 esterase inhib...

BACHEM is a global CDMO, supporting approximately 150 new chemical entity (NCE) projects across all development stages. Building on 50+ years of experience in peptides manufacturing, BACHEM has leveraged its expertise towards oligonucleotides production in 2018. Strong from technical and regulatory experie...

Fields of Application: Conjunctivitis.  Antazoline Hydrochloride is an ethylenediamine derivative with antihistaminic properties and is used in conjunction with a vasoconstrictor for ocular allergies.

Fields of Application: Conjunctivitis. Antazoline Hydrochloride is an ethylenediamine derivative with antihistaminic properties and is used in conjunction with a vasoconstrictor for ocular allergies.

Fields of Application: Conjunctivitis. Antazoline Sulsphate is an ethylenediamine derivative with antihistaminic properties and is used in conjunction with a vasoconstrictor for ocular allergies.

Fields of Application: Anesthesia. Etomidate is a rapid, short acting intravenous anesthetic agent with no analgesic properties and a relative lack of significant hemodynamic and respiratory effects.

Fields of Application: Sedation, Anesthesia. Propofol is an intravenous, short acting anesthetic with rapid onset of action.

Fields of Application: Premature labor. Atosiban is an oxytocin and vasopressin antagonist. It is used as a tocolytic in the management of preterm labor.

Fields of Application: Moderate to high risk acute coronary syndromes. Percutaneous coronary intervention. Bivalirudin is a hirudin analog. It acts as a specific and reversible direct thrombin inhibitor.

Fields of Application: Use in reproduction medicine. Advanced hormone-dependent prostate cancer Endometriosis, Central precocious puberty, Uterine myoma. Buserelin is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a su...

Fields of Application: Nocturnal enuresis, Central diabetes insipidus, polyuria, polydipsia, Mild and moderate forms of hemophilia A and von Willebrand disease. Desmopressin is a synthetic analog of vasopressin with low vasopressor activity. Apart from its increasing effect on water resorption by the kidne...

In our studies in collaboration with Novo Nordisk, we set out to identify environmentally benign solvents suitable for large-scale SPPS of peptide therapeutics at ambient temperature by assessing reagent solubility, resin swelling, amino acid coupling and Fmoc-removal efficiency in a collection of REACH compatible neat solvents and selected binary solvent mixtures. These studies have shown that binary solvent mixtures are indeed viable alternatives.

Microparticle formulation has been successfully applied in a number of commercial products containing peptides as APIs. The use of nanoparticles for delivering proteins and peptides are still in early stages of development. Discover how Bachem is part of this technology!

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