Bachem & Novo Nordisk Redesign SPPS for Green Chemistry
In our studies in collaboration with Novo Nordisk, we set out to identify environmentally benign solvents suitable for large-scale SPPS of peptide therapeutics at ambient temperature by assessing reagent solubility, resin swelling, amino acid coupling and Fmoc-removal efficiency in a collection of REACH compatible neat solvents and selected binary solvent mixtures. These studies have shown that binary solvent mixtures are indeed viable alternatives.
Replacing gold standard solvents to provide a greener alternative: new binary solvents are a good alternative to DMF and mitigate common side reactions in SPPS.
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