(Arg8)-Vasopressin

Fields of Application: Osteoporosis - not yet an approved application. pTH (1-34) (human) Acetate administered in low dosage and intermittently stimulates bone formation.

Fields of Application: Ulcer bleeding, Hemorrhagic gastritis, Postoperative pancreatic and duodenal fistulae, Variceal hemorrhage. Somatostatin is an inhibitor of growth hormone release from the anterior pituitary and suppresses the release of a variety of other hormones involved in the regulation of impor...

Fields of Application: Investigation of adrenocortical insufficiency, Neurological diseases, Rheumatic diseases, Skin diseases, Diseases of the intestinal tract, Oncology. Tetracosactide is a synthetic peptide that corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorti...

Fields of Application: Advanced hormone-dependent prostate cancer, Use in reproductive medicine, Endometriosis, Central precocious puberty. Triptorelin Acetate is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppre...

Fields of Application: Advanced hormone-dependent prostate cancer. Triptorelin Pamoate is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.

Fields of Application: Diabetes II Active Substance: Exendin-4 (exenatide), a 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increa...

Icatibant Acetate is a selective competitive antagonist for the bradykinin B2 receptor. It is indicated for the treatment of acute attacks of hereditary angioedema (HAE). HAE is a rare disorder resulting in periodic attacks of acute edema. It is characterized by a deficiency of functional C1 esterase inhib...

BACHEM is a global CDMO, supporting approximately 150 new chemical entity (NCE) projects across all development stages. Building on 50+ years of experience in peptides manufacturing, BACHEM has leveraged its expertise towards oligonucleotides production in 2018. Strong from technical and regulatory experie...

Fields of Application: Conjunctivitis.  Antazoline Hydrochloride is an ethylenediamine derivative with antihistaminic properties and is used in conjunction with a vasoconstrictor for ocular allergies.

Fields of Application: Conjunctivitis. Antazoline Hydrochloride is an ethylenediamine derivative with antihistaminic properties and is used in conjunction with a vasoconstrictor for ocular allergies.

Fields of Application: Conjunctivitis. Antazoline Sulsphate is an ethylenediamine derivative with antihistaminic properties and is used in conjunction with a vasoconstrictor for ocular allergies.

Fields of Application: Parkinson's disease. Carbidopa, an aromatic L-amino acid decarboxylase inhibitor, which does not cross the blood-brain barrier, is routinely administered in combination with levodopa to patients with Parkinson’s disease to reduce the peripheral decarboxylation of levodopa to dopamine.

In our studies in collaboration with Novo Nordisk, we set out to identify environmentally benign solvents suitable for large-scale SPPS of peptide therapeutics at ambient temperature by assessing reagent solubility, resin swelling, amino acid coupling and Fmoc-removal efficiency in a collection of REACH compatible neat solvents and selected binary solvent mixtures. These studies have shown that binary solvent mixtures are indeed viable alternatives.

Microparticle formulation has been successfully applied in a number of commercial products containing peptides as APIs. The use of nanoparticles for delivering proteins and peptides are still in early stages of development. Discover how Bachem is part of this technology!

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