BioDuro Collaboration with Pfizer Inc. Leads to Creation of a Shelf-Stable Fluorosulfation Reagent

BioDuro announces creation of AISF ([4-(Acetylamino)phenyl]-ImidodiSulfuryl diFluoride), a convenient, shelf-stable, crystalline reagent for the synthesis of fluorosulfates and sulfamoyl fluorides, in a research collaboration with Pfizer.

While fluorosulfates have immense potential applications, from chemical biology to polymer chemistry, the currently utilized method of synthesis relies on the use of sulfuryl fluoride gas. Because sulfuryl fluoride gas is a colorless, odorless and toxic gas that requires specialized equipment and additional safety precautions when using, this potentially valuable functional group has previously not been fully evaluated or broadly adopted.
Three important attributes were sought for a solid reagent alternative to sulfuryl fluoride gas:

• The reagent must demonstrate comparable or improved reactivity to sulfuryl fluoride gas. 
• It must be a crystalline, shelf-stable and easily manipulated solid. 
•  It must be readily accessible for manufacturing on a large scale from commercially available starting materials.    

The creation and development of AISF into a commercially viable and environmentally safe product is a result of a breakthrough from deeply committed and engaged scientists from both BioDuro's and Pfizer's chemistry teams.