PolyCYPs kits for the synthesis of oxidized metabolites

PolyCYPs Metabolite KitsEasy-to-use in-vitro enzyme system for generation of CYP, AO and FMO derived metabolites of drugs, agrochemicals and other small molecules


PolyCYPs+ metabolite kits are used by scientists in pharmaceutical and agrochemical companies to screen for and scale-up human and other mammalian phase I metabolites.

Hypha’s PolyCYPs enzymes are mined from talented biotransforming strains in  our collection, and are capable of oxidising groups in a wide range of substrate compounds, including arylic/benzylic, -CH, -CH2, -CH3, –tert-butyl, and iso-propyl moieties, as well as aromatic systems for phenols and epoxides. De-alkylation of N– and O-alkyl moieties is also observed. 


Individual "hit" enzymes can be resupplied, alternatively Hypha supports scale up production by mg-gram scale synthesis, purification and identification of target metabolites.