Labrasol

Gelucire® 50/13 (stearoyl polyoxyl-32 glycerides) is a nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs. Self-emulsifies in aqueous media forming a fine dispersion, i.e., microemulsion (SMEDDS).

Labrafac™ lipophile WL 1349 is an oily vehicle and solubilizer of lipophilic APIs for oral, topical, and parenteral lipid-based formulations (LBFs).

Labrafac™ PG is a an oily vehicle and solubilizer for lipophilic APIs in topical dosage forms. Widely used as a vehicle in veterinary parenteral formulations.

Labrafil® M 1944 CS (oleoyl polyoxyl-6 glycerides ) is a nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs. Self-emulsifies in aqueous media forming a coarse dispersion, i.e., emulsion (SEDDS). Co-emulsifier ...

Labrafil® M 2125 CS (linoleoyl Polyoxyl-6 glycerides) is a nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs. Self-emulsifies in aqueous media forming a coarse dispersion, i.e., emulsion (SEDDS). Co-emulsifier in ...

Labrafil® M 2130 CS (lauroyl polyoxyl-6 glycérides) is a nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly soluble APIs. Self-emulsifies in aqueous media forming a coarse dispersion, i.e., emulsion (SEDDS). Co-emulsifier in topical ...

Labrasol® ALF (caprylocaproyl Polyoxyl-8 glycérides) is a nonionic water-dispersible surfactant for lipid-based formulations to solubilize and increase oral bioavailability of poorly water-soluble APIs. Self-emulsifies in aqueous media forming a fine dispersion, i.e., microemulsion (SMEDDS).

Lauroglycol™ 90 (propylene glycol monolaurate) is a nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms.

Lauroglycol™ FCC is a nonionic water-insoluble surfactant used as cosurfactant in oral lipid-based formulation SEDDS and SMEDDS. Cosurfactant and solubilizer in topical dosage forms associated with skin penetration enhancement.

Monosteol™ is a lipidic vehicle used as consistency agent in topical formulations. Enhances stability by preventing phase separation and oil droplet coalescence.

Ovucire® 3460 is a hard fat pessary base delivering enhanced spreadability within the vaginal cavity and good mechanical resistance. Non-irritant providing excellent mucosal tolerance.

Ovucire® WL 3264 is a hard fat pessary base with emulsifier to improve dispersibility and wettability of hydrophobic APIs.

Discover Gelucire® 59/14, an add-on in Gattefossé Gelucire® range, for oral bioavailability enhancement

Selecting best excipient

Discover Labrafac™ MC60, glycerol monocaprylocaprate, an oral bioavailability enhancer.

This session was originally broadcast as part of the CPHI Worldwide 2021 digital content programme. Patient adherence to skin treatments Bi-gels: formulating new topical drugs Emulfree® Duo, a ready-to-use excipient designed to make bi-gels Case studies

Discover our brand new excipient Emulfree® Duo, a ready-to-use stabilizing agent, enabler of bi-gel, an emerging topical dosage form.

This session was originally broadcast as part of the CPHI Worldwide 2021 digital content programme. This session explores: Using Lipid-based formulations to address oral bioavailability issues Labrafac™ MC60, glycerol monocaprylocaprate, Gattefossé new bioehancer Case study: step-by-step development of a lipid-based formulation of dutasteride with Labrafac™ MC60 Gattefossé technical expertise

Many drugs exhibit poor solubility and/or permeability leading to weak oral bioavailability. To overcome these issues, different technologies have been developed. Among them, lipid-based formulation (LBF) is an option worth considering as it can be used from the very beginning of drug development to product, reducing time to market.