Fumaric Acid

Fumaric Acid USP NF

C4H4O4 --- 116.07
2-Butenedioic acid, E-.
Fumaric acid [110-17-8].

Fumaric Acid contains not less than 99.5 percent and not more than 100.5 percent of C4H4O4, calculated on the anhydrous basis.

Identification: Dissolve about 10 mg in 25 mL of water, and to this solution add 1 mL of a solution prepared by mixing 20 mL of copper sulfate solution (1 in 5) and 8 mL of pyridine: a precipitate is formed in the blue solution within 1 minute.
Water: 0.5%.
Residue: not more than 0.1%.
Heavy metals: 0.001%.
Limit of maleic acid: To pass the test. Not more than 0.1% of maleic acid is found.
Organic volatile impurities: meets the requirements.
Assay: Transfer about 1 g of Fumaric Acid, accurately weighed, to a conical flask, add 50 mL of methanol, and warm gently on a steam bath to effect solution. Cool, add phenolphthalein TS, and titrate with 0.5 N sodium hydroxide VS to the first appearance of a pink color that persists for not less than 30 seconds. Perform a blank titration, and make any necessary correction. Each mL of 0.5 N sodium hydroxide is equivalent to 29.02 mg of C4H4O4.