Continuous Crystallization Technology

Pervaporation is a liquid/liquid separation process using a selective and dense membrane. 

By creating a vacuum or introducing a flow of purge gas on one side of a dense membrane, volatile compounds in the liquid present on the other side will selectively diffuse through the membrane....

On the basis of microfluidic principles, Secoya develops and supplies a novel emulsification technology – RayDrop®- for the production of monodispersed droplets or particles. 

The emulsification process in the RayDrop® is based on co-flow and flow-focusing technologies embedded in a ...

As a service provider, Secoya develops new synthesis processes mostly based on flow chemistry. By downscaling reactor size, an optimal control of the process is achieved, enabling production of products with very high quality attributes. Secoya has a robust expertise in this field and has developed a metho...

The SCT-LAB equipment is designed for a fast and accurate parameter sweep of crystallization conditions based on Secoya’s crystallization technology. Its comprehensive software enables the user for fast and easy use of the syringe pumps. As the software can be installed on external devices, the unit itself...

The emulsification platform is an integrative, fast and easy screening tool to set up emulsification processes such as simple and double emulsions using Secoya’s emulsification technology: the Raydrop. It includes a comprehensive flow path with pressure controllers, filters, flowmeters, and valves to ea...

A brief overview of the problems in pharmacetucial production industry where Secoya Technologies can provide solution.

Secoya Technologies is a tech-provider for different domains (crystallization, single & double emulsification, encapsulation, pervaporation, process intensification) enabling the development as well as the production of (bio-)pharmaceutical products.

On the basis of microfluidic principles, Secoya develops and supplies a novel technology – RayDrop®- for the production of monodispersed droplets or particles. 

The emulsification process in the RayDrop® is based on co-flow and flow-focusing technologies embedded in a stainless-steel housing. Furthermore, the RayDrop® integrates the possibility to produce double emulsion (W/O/W, O/W/O), e.g. for the production of core/shell particles or capsules.

Monodispersed PLGA particles are easily produced using the RayDrop® technology with particle size from 10 up to 200 µm and without the use of chlorinated solvent. The technology is suitable for the efficient encapsulation of any active ingredients, being either hydrophobic or hydrophilic. 

In this introductory webinar, the Secoya Crystallization Technology is demonstrated. This technology focuses on the use of millifluidic capillary reactors that enable the most profound control on all crystallization parameters, making spontaneous nucleation controllable and exploitable. Several examples using organic molecules like active pharmaceutical ingredients are shown, also pinpointing to the way the nucleation can be controlled to crystallize the polymorphic form of choice and at the same time steer the process towards the final desired material attributes, especially size. As such, the complex multi-step process of crystallization (seed preparation, crystal growth, isolation, milling, etc.) is reduced to a simple setup where the nucleation, growth and isolation of organic or inorganic compounds are fully coupled from the (heated) solution to a crystalline material.