Celldex Presents Data from Rindopepimut Phase II Trial
Data demonstrated a median overall survival of 24.6 months from diagnosis, which is consistent with the finding of two earlier studies.
MA-based Celldex Therapeutics has presented mature overall survival data from a Phase II trial of rindopepimut (CDX-110) in patients with EGFRvIII-positive glioblastoma.
Rindopepimut is an immunotherapeutic vaccine that acts by targeting tumour-specific oncogene EGFRvIII.
Data from the multicentre, single-arm ACT III study demonstrated a median overall survival of 24.6 months from diagnosis, which is consistent with the finding of two earlier studies.
The study also revealed a two-year survival rate of 52%, again similar to the previous studies, which indicated a 50% survival rate at two years.
Rose Lai, lead
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