Aseptic fill and finish

Aseptic fill and finish
Product Description

We offer solutions for companies that need CMO capacity concerning the aseptic filling of syringes and assembly and packaging of pre-filled syringes and auto-injectors. We will enhance your product by adding value through manufacturing if you require additional capacity or a complete technology transfer.

Our aseptic fill and finish capabilities for high-potent APIs include aseptic filling of syringes, made available in nests and tubs, ranging from 0.2 ml to 50 ml, and testing and assembly of pre-filled syringes in auto-injectors. We handle compounding isolators, filling isolators, and solution handling from a disposable bag via single-use tubing.

Our capabilities include a state-of-the-art automatic aseptic filling machine performed in an isolator of syringes, available in nests/tubs with an option of filling with nitrogen flushing during stoppering.

We also offer assembly of pre-filled syringes in auto-inject...

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Sever Pharma Solutions

  • SE
  • 2023
    On CPHI since
  • 250 - 499
    Employees
Company types
CMO/CDMO
View company profile
Categories
more categories Show less

Sever Pharma Solutions

  • SE
  • 2023
    On CPHI since
  • 250 - 499
    Employees
Company types
CMO/CDMO
View company profile

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Sever Pharma Solutions resources (3)

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    Download our free whitepaper on the design of intra-vaginal drug-releasing rings (IVRs) and the importance of avoiding unnecessary design complexity. You will also get the background on IVR development, which includes polymer selection and drug release kinetics, and learn more about simultaneous drug release.
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    Whitepaper A COMPARISON OF SATURATED SOLUBILITY ENHANCEMENT VIA SPRAY DRYING AND HOT MELT EXTRUSION PROCESSING

    Solid solutions are similar to liquid solutions and consist of a single phase irrespective of the number of components. A solid solution of a poorly water-soluble drug dissolved in a carrier is particularly interesting in improving oral bioavailability. In a solid solution, the drug’s particle size has been reduced to its molecular dimensions resulting in a more rapid dissolution rate. By judicious selection of a carrier, the dissolution rate of the drug can be increased by up to several orders of magnitude. In a solid solution, the drug’s particle size has been reduced to its molecular dimensions resulting in a more rapid dissolution rate.

    This whitepaper compares solubility enhancement between spray drying and hot melt extrusion for a poorly soluble, new active pharmaceutical ingredient.

  • ANALYTICAL TOOLS & TECHNIQUES IN HOT MELT EXTRUSION - CASE STUDY ON PROCESS SCALE UP

    Whitepaper ANALYTICAL TOOLS & TECHNIQUES IN HOT MELT EXTRUSION - CASE STUDY ON PROCESS SCALE UP

    Hot melt extrusion has been widely used as a processing method for many purposes, including forming a solid molecular dispersion to increase the bioavailability of poorly soluble drugs. Analytical tools and techniques can significantly reduce time and improve success rates in developing hot melt extrusion formulations.

    In the scale-up phase, analytical characterization techniques ensure similar solubility enhancement occurs on larger extrusion equipment as with the lab scale equipment used for formulation development.

    In this whitepaper, you will learn more about the analytical characterization and techniques that are critical in the scale-up of melt-extruded solid dispersions to ensure similar products are produced, specifically in obtaining similar solubility-enhancing effects.