Whitepaper
6 Sep 2023
ANALYTICAL TOOLS & TECHNIQUES IN HOT MELT EXTRUSION - CASE STUDY ON PROCESS SCALE UP
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Sever Pharma Solutions
![Sever Pharma Solutions](/Sever_black_colour-comp309342.jpg)
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SE
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2023On CPHI since
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250 - 499Employees
Company types
Other Content from Sever Pharma Solutions (2)
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Whitepaper Design of intra-vaginal drug-releasing rings
Download our free whitepaper on the design of intra-vaginal drug-releasing rings (IVRs) and the importance of avoiding unnecessary design complexity. You will also get the background on IVR development, which includes polymer selection and drug release kinetics, and learn more about simultaneous drug release. -
Whitepaper A COMPARISON OF SATURATED SOLUBILITY ENHANCEMENT VIA SPRAY DRYING AND HOT MELT EXTRUSION PROCESSING
Solid solutions are similar to liquid solutions and consist of a single phase irrespective of the number of components. A solid solution of a poorly water-soluble drug dissolved in a carrier is particularly interesting in improving oral bioavailability. In a solid solution, the drug’s particle size has been reduced to its molecular dimensions resulting in a more rapid dissolution rate. By judicious selection of a carrier, the dissolution rate of the drug can be increased by up to several orders of magnitude. In a solid solution, the drug’s particle size has been reduced to its molecular dimensions resulting in a more rapid dissolution rate.
This whitepaper compares solubility enhancement between spray drying and hot melt extrusion for a poorly soluble, new active pharmaceutical ingredient.
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