Application Of Betadex Sulfobutyl Ether Sodium In Eye Drops 182410-00-0

Name: Betadex Sulfobutyl Ether Sodium

CAS: 182410-00-0

Molecular weight: 1135+158n

Quality: Injection grade

Standard: USP/EP

Package: 500g/bag,1kg/bag,10kg/drum or customizedThe role in ophthalmic medicine

Betadex sulfobutyl ether sodium has little stimulation on cornea and can reduce the irritation of drugs on the eyeball, so it is very suitable for the preparation of eye drops with physiological pH and osmotic pressure requirements.

Ganciclovir was soluble in water, but the water solubility was significantly affected by pH, more easily in dissolved under acidic conditions. The pH and osmotic pressure of the eyedrops are strictly required. The results showed that the Betadex sulfobutyl ether sodium in the prescription significantly reduced the eye irritation of ganciclovir, and the inclusion of Betadex sulfobutyl ether sodium on the drug could increase the biocompatibility of the eye drops.

O,O’-Dipropionyl-(1,4-xylylene) bispilocarpate is a precursor of trabeculin, a drug for glaucoma treatment. It has a strong irritation to the eye and affects its clinical application. After adding Betadex sulfobutyl ether sodium to the prescription of the eye drops, it was found that the irritation of Betadex sulfobutyl ether sodium eye drops to rabbit eyes was significantly reduced within the range of 24 ~ 36mmol. L-1. The mechanism may be that when the drug forms a inclusion compound with Betadex sulfobutyl ether sodium, the inclusion compound can slowly release the drug in the eye, so as to reduce the local concentration of the free drug and reduce or eliminate the eye irritation caused by the rapid absorption or precipitation of the drug.