Single Use Support GmbH

RoSS.FILL is a fully automated filling & draining system for single-use bags and bottles in different sizes and quantities. It facilitates maximum flexibility and scalability of both the filling and draining process. It is possible to attach filling racks for unlimited volumes per batch with ...

The plate-based freeze-thaw platforms from Single Use Support enable controlled freezing and thawing of drug substances. Transferable recipes enable full scalability and compatibility from the lab to blockbuster production. Thanks to RoSS technology all batch sizes and single-use bags from all establi...

Protect your single-use bioprocess containers: RoSS® Shells - abbreviated for Robust Storage and Shipping - reduce product loss towards 0%. Compatible with all available sizes and types of single-use bags, RoSS enables standardized and scalable end-to-end process solutions for fluid management and col...

Primary packaging for your highly quality product! Our tried-and-tested single-use bag ensures a 100% secure primary packaging for your product handling. Store, ship and freeze anything from cell culture samples to large volume drug substances. IRIS Single-Use Bags are fully qualified for the usage...

Get your customized IRIS single-use assembly & tubing system based on different tubing modules and aseptic connectors directly from Single Use Support. As an expert in single-use solutions, we have made it our goal to deliver vendor agnostic single-use assemblies manufactured with highest qu...

RoSS.PADL is a platform to standardize cooling/heating of your single-use bag while it is gently kneaded to ensure a homogenous mixture of your substance. The cooling/heating mechanism ensures that the correct temperature is maintained. In addition, the biocontainer can be filled during the p...

RoSS.FRDG is an upright ultra-cold storage freezer for frozen drug substances in different sizes. The fridge for laboratories keeps the desired set point temperature down to -75°C. 
More: https://www.susupport.com/solutions/platform-systems/freeze-thaw-system/cold-storage

RoSS.LN2F is a powerful cryogenic controlled rate freezer for cryogenic freezing down to -170°C/-274°F. An enclosed and innovative platform system for dosed freezing for cell and gene therapies eliminates direct exposure and the need for mechanical compressors. This ensures safe, low maintenance ...

Advanced Fluid Management for Cell Culture Freezing, Cell Banking and Cell Therapy

Cells are important building blocks for today’s medicine and novel advanced therapies. FDA approvals for CAR-T cell therapies can be seen as proof for their ability to provide answers for many previously incurable diseases. The range of applications for cells utilized in the biopharmaceutical industry is very broad. The same is true for manufacturing processes for such therapies. The diversity of applications, be it for cell therapies, cell banking or cell culture suspension, adds to the complexity of cell-based manufacturing, which means that there is not a uniform fluid management process that applies to all cell-based suspensions. Sterile aliquotation into single-use bioprocess containers and freezing for cryopreservation of cells pose challenges for laboratories and manufacturers.

As one of the most essential parameters in terms of achieving control over freezing & thawing bulk, the freezing rate has been considered and evaluated in different tests. The leverage of the ice front growth speed had a significant impact on controllability and, as a result, on the protein quality.

A global biotechnology company produces different drug substances of highly valuables monoclonal antibodies (mABs). The company experienced a product loss rate between 0,5% and 5% due to the sensitivity of single-use bioprocess containers at sub-zero temperatures. Therefore, the goal was to reduce the current product loss below 0.5%.

This case study discloses how the implementation of RoSS® technologies from Single Use Support had an impact on the product loss during trials of hundreds of single-use bags. 

You will be surprised of the cost savings due to reduced product loss.