2-Hydroxypropyl-β-cyclodextrin

2-Hydroxypropyl-β-cyclodextrin

Technical Information
Formal Name:2-hydroxypropyl ethers β-cyclodextrin
CAS Number: 128446-35-5
Synonyms: HP-β-CD
Molecular Formula: (C6H9O5)7(C3H7O)
Formula Weight: 1541.6
Purity: ≥98%
Formulation: A crystalline solid
Shipping & Storage Information
Storage: Room temperature
Shipping: Room Temperature in continental US; may vary elsewhere
Stability: 2 years

Product Description

2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group.1,2,3 The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the HP-β-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility.