Ushyal

Ushyal is indicated in the treatment of symptoms of skin hyperkeratosis, such as redness and scaling, and in the localised treatment of mild to moderate plaque psoriasis. The product is a topical emulsion with a protective and soothing action. It helps protect against over infection.


HOW IT WORKS

• Usnic acid (UA) is one of the most common and abundant lichen metabolites. It belongs to the dibenzofuran family and can be isolated from Usnea longissima, U. articulate, U. complanata, U. meridionalis, U. barbata and Cladonia arbuscula, among other species (White PA, et al. Molecules 2014;19:14496-527). Several biological properties have been observed from this compound, such as gastroprotective, cardiovascular and cytoprotective, immuno-stimulatory, antimicrobial, anti-inflammatory and anticarcinogenic activities, mostly through its antioxidant action in reducing oxidative damage (White PA, et al. Molecules 2014;19:14496-527)
• Hyaluronic acid (HA) is a large glycosaminoglycan (carbohydrate polymer) that is abundant in many tissues, where it acts as a hydrating agent and an organizer of proteins that form structural scaffolding in tissues such as cartilage and dermis (Noble PW. Matrix Biol. 2002; 21:25–29). HA is an active regulator of many dynamic cellular processes and it facilitates cell proliferation and migration during embryonic tissue development, wound repair, cell locomotion, and tumor invasion (Lee JY, Spicer AP. Curr Opin Cell Biol. 2000;12:581–586). It has been showed that HA has an important regulatory role in epidermal hyperplasia and in epidermal response to injury (Maytin EV, et al. Am J Pathol. 2004 Oct;165(4):1331-41). The hyperplastic response to barrier disruption appears to be a pathogenic feature in psoriasis (Ghadially R. J Invest Dermatol. 1996; 107:558–564).