CPHI Online is the largest global marketplace in the pharma ingredients industry

  • Products
    0
  • Companies
    0
  • Articles
    0
  • Events
    0
  • Webinars
    0

Twin-screw extrusion - hot melt extrusion

Twin-screw extrusion - hot melt extrusion
Product Description

Hot melt extrusion is a commonly applied continuous technology to fabricate amorphous solid dispersions of poorly soluble drugs to enhance the dissolution and the bioavailability. The API and the polymer are getting molten due to the high shear forces and elevated temperature followed by complete homogenization of the components. When the extrudate exits the die attached to the equipment, it solidifies suddenly providing no chance for the API to crystallize. Afterward, the extrudate can be forwarded for milling e.g. with a conveying belt. With continuous extrusion, you can minimize your material cost by reducing the amount of API needed for feasibility studies.

Xedev

  • BE
  • 2016
    On CPHI since
  • 1
    Certificates
  • 1 - 24
    Employees
Company types
CMO/CDMO
Primary activities
Biopharmaceutical
Contract Manufacturer
Contract Research Organisation
Laboratory Services
Specifications
  • Selling Points
    Experienced Technicians; Quality Service

Xedev

  • BE
  • 2016
    On CPHI since
  • 1
    Certificates
  • 1 - 24
    Employees
Company types
CMO/CDMO
Primary activities
Biopharmaceutical
Contract Manufacturer
Contract Research Organisation
Laboratory Services

More Products from Xedev (10)

  • Spray-drying

    Product Spray-drying

    Spray-drying is an instant and continuous solvent evaporation process of a liquid feed, atomised in a heated gas, generating a final dried solidified particle.The heated drying gas moves in co-flow with the atomised feed in the process chamber where the gas transfers its heat energy to the droplets and abs...
  • Formulation and process development

    Product Formulation and process development

    Do you have an NCE that needs to be formulated in a solid dosage form or having challenging process and formulation questions, then XEDEV is your partner to assist you, as we are specialised in formulation and process development through drying, granulation, tableting and/or coating processes.

    P...
  • Development Oral Solid Dosage forms

    Product Development Oral Solid Dosage forms

    XEDEV provides wide range of technologies going from powder to tablet in order to develop your final oral solid dosage form. • spray-drying • encapsulation • granulation (wet, dry and hot) (batch and continuous) • tableting • coating Contact us for more information.
  • Analytical package

    Product Analytical package

    XEDEV provides a broad range of analytical tools including : • Solid state analysis: mDSC, XRPD, PLM, TGA, FTIR, RAMAN • Powder characterisation : SEM, PSD (both wet and dry), flowability • Tablet characterisation : friability, disintegration, hardness, dissolution • Residual solvent determination :...
  • Fluid bed dryer/coater/agglomerator

    Product Fluid bed dryer/coater/agglomerator

    Xedev provides wide range of technologies which includes fluid bed dryer/coater/agglomerator. Contact us for more information.
  • Hot melt twin screw extruder

    Product Hot melt twin screw extruder

    Xedev provides wide range of technologies which includes hot melt twin screw extruder. Contact us for more information.
  • Perforated drum tablet/capsule coater

    Product Perforated drum tablet/capsule coater

    Xedev provides wide range of technologies which includes perforated drum tablet/capsule coater. Contact us for more information.
  • Agitated vaccum dryer

    Product Agitated vaccum dryer

    Xedev provides wide range of technologies which includes agitated vaccum dryer. Contact us for more information.
  • CDMO services - Spray-drying

    Product CDMO services - Spray-drying

    Xedev can perform the clinical production for your spray-drying project.
  • Clinical batch production

    Product Clinical batch production

    XEDEV can support clinical batch manufacturing up to Phase IIb in our clean rooms after succesfull development.

Xedev resources (1)

Frequently Viewed Together

  • Product FlowKiloLab

    Modular plants accelerate time-to-market by using the same infrastructure for development and manufacturing. Production capacities adjust quickly, enabling faster product launches without long construction times. The use of scalable equipment enables a fast scaleup.

    Module Type Package Proto...
  • Product PLANETA

    MG2 PLANETA capsule filling machine distinguishes itself by its high technology, quality and reliability.The modular design of PLANETA means flexibility and ease of use, characteristics which make this capsule filling machine ideal for R&D laboratories as we...
  • Product Laser Printing Inspection Machine

    PLANET LPI, UV laser printing and complete vision inspection was developed based on our cumulated technologies and accurate positioning as per shape tracing, which draws the innovative result and eliminating lots of traditional troubles such as distortion of print, out of position, and etc.
    qq...
  • Product Filling & Closing Machines for Liquid Products in Nested Syringes (RTF)

    Groninger & Co. Gmbh offers a wide range of products which includes nested syringes. It perfected the efficient processing of nested pre-sterilized syringes. Technical solution prevent any possibility of microbiological contamination. High flexibility, short changeover times and excellent processing qu...
  • Product JTFZ Series Lifting Tipper With Mill

    JTFZ Series Lifting Tipper with on-line dry cone mill is used for unloading and transferring the dried or granulated products from material bowl of fluid-bed granulator,and after dry milling then to blender bin or sieving.
  • Product Smart_Projector Pharma

    The Next Generation Video Measuring Machine for Primary Pharmaceutical Packaging: Smart_Projector Pharma allows automatic, objective, repeatable, easy and fast dimensional quality check of any cylindrical parts.

    Easy and FastSmart_Projector Pharma by SmartVision is the first and unique instrumen...
  • Product Humodar C25 100 R

    PRJSC "Indar" provides wide range of insulin products in vials and cartridges which includes humodar c25 100r. Its an anti-diabetic product of short effect. Ensures quick decrease of glucose level in the blood, intensifies its absorption by tissues. The effect starts after 30 minutes and can last within 5-...
  • Product Inspection for Glass Containers - RS1

    The automatic inspection machine RS1 has been projected to integrate CMP's know-how and experience in camera based visual inspection and HVLD (High Voltage Leak Detection) system. The machine is equipped with 4 leak test stations and a rotation system in order to improve the quality of the inspection. ...
  • Product Cleanroom / Laminar Flow

    From the first idea to the turnkey clean room - ASYS Prozess- und Reinraumtechnik develops individual solutions from clean workplaces, laminar flow units to drying storage cabinets and dynamic storage systems. With our solutions you protect your products in production according to GMP, ISO and VDI.
  • Product Omag Packaging Machine mod.CS

    Intermittent motion packaging machine to pack products into tubolar stick-pack.
  • Product Autoinjectors & pens

    Proven track record in managing parenteral customized solution and large scale industrialization projects of Autoinjectors and Pens with top pharmaceutical companies.

    Our offer:

    - disposable & reusable pen injectors
    - Taylor-made autoinjectors & pens
  • Product PAPI - Potent API Processing Isolator

    Comecer isolators for containment requirements are conceived for pharmaceutical companies who require high-level protection during potent API processing. Comecer PAPI isolators for potent API processing can be equipped with a variety of devices for any kind of process: reactors skid, vacuum ovens, ...
  • Product FS 200 - The perfect solution for clean room applications

    For IVD, POC, gel cards, and more look no further than the FS 200. Designed for installation in clean rooms and equipped with a rotary indexing table with 8 stations that can be configured in the most flexible manner, the FS 200 forms, assembles, fills, and seals even the most complex products with great p...
  • Product Physical characterization techniques for pharmaceuticals

    Intertek offers wide range of pharmaceutical services which includes physical characterization techniques for pharmaceuticals. Our experts can assist with formulation or process development, quality control, gmp lot release testing, and investigational manufacturing troubleshooting. It includes microscopy,...
  • Product EPDM Isolator Gloves

    The glovebox glove TRON 5000 is an excellent glove with its exceptional resistance against oxygen, ozone based aging, UV rays, steam, heat and chemical products.
    It is recommended when working with oxidizing products, concentrated nitric acid, concentrated alkalis and alcohols.

  • Product Flexible Production Systems

    // Looking for the greatest possible flexibility in your pharma production? We have the perfect solution. ///

    In the pharmaceutical industry nothing stays the same for very long. There are always new processes, challenges, and developments to contend with.I...
  • Product GPX1500 Vial

    The Gasporox GPX1500 Vial represents a new approach to headspace oxygen gas inspection – fast, accurate, non-intrusive and non-destructive, in tubular vials. 
    The GPX1500 Vial is a very compact and easy to use instrument to measure accurate the headspace of pharmaceutical containers. Change over ...
  • Product Biosafe® Simplifies Your Transfer of Closure Components

    Secure Your Aseptic Transfer

    With the robust design and proven performance of the Biosafe® RTP system (Rapid Transfer Port) you can secure and simplify the transfer of your components, monitoring tools and liquids into your isolated line. Biosafe® bags exits in RTU (Ready to Use) and R...
  • Product Complete lines for sachet and stick-packs in cartons

    Universal Pack Synthesis complete automatic packaging Lines are individually custom-built, whether for primary or secondary packaging,  guaranteeing the highest efficiency together with the most compact machine layout, perfectly in line with Universal Pack traditional concepts.
  • Product CLF-IS - Compact laminar flow isolator system

    The Compact Laminar Flow Isolator System is a modular cGMP Class A/ISO 5 isolator system specifically designed for safe handling of hazardous compounds (Chemotherapy, Oncological Applications) in hospital pharmacies.
  • Product Zeta - Pharmaceutical freeze drying systems

    For GMP processes in pharmaceutical applications, we offer the Zeta freeze dryer series featuring the dual-chamber principle. The big integrated intermediate valve separates the two parts: product chamber and ice condenser. The large opening provides ideal flow conditions for water vapour. The dual-chamber...
  • Product Oral Liquid / Syrup / Suspension Manufacturing Plant

    The Oral Liquid / Syrup / Suspension Manufacturing Plant system consists of a closed-circuit manufacturing facility, from feeding the Sugar/ Water phases to loading the Volumetric Liquid Filling Machine. It consists of the following items: Capacity: 500 Liters to 15000 Liters 
    BRIEF ...
  • Product QGF Series IV Solution Plastic-bottle Wash-Fill-Seal Machine other api e...

    QGF Series IV Solution Plastic-bottle Wash-Fill-Seal Machine, is a world advanced standard pharmaceutical equipment, designed on the market demand and combined the advantages of identical machine of domestic and abroad.
  • Product Commercial Storage and Distribution

    Complementing our commercial manufacturing and packaging services, we provide a range of commercial storage and distribution solutions for solid oral dosage forms and sterile biopharmaceuticals, for both niche / orphan drug products and large scale commercial market volumes.

    Utilising our bespok...
  • Product SPINE

    All-in-one 360° visual inspection machine with 3D and 2D inspection technology for inspection and sorting of tablets, capsules and softgels. Sensum SPINE automatically inspects the entire surface of tablets, capsules and softgels at the speed of up to 630.000 products/hour. Machine can inspect an ex...
  • Product Purified Water Plants

    Pure water generation plants by Stilmas are the result of many years of experience and constant technical development. They represent the simplest, safest and most reliable water purification method for: Production of ultra-pure water for pharmaceutical / Cosmetic and food industries / Production o...
  • Product WAB IMPA°CT REACTOR

    An inductively heated mechanochemical reactor for continuous mechanochemistry, the WAB IMPA°CT REACTOR is our latest innovation in the field of flow chemistry. An induction heater arranged around the stirring elements heats the reactants directly and efficiently up to +160 °C.

    ...
  • Product Rommelag SERVICE

    Rommelag offers the system configuration tailored to the product, supports you with the in-house pharmaceutical service already during the planning phase and provides classic after-sales service from installation of the system by our own technicians to maintenance, repair and complex modifications and ...
  • Product Clamp Connections acc. to DIN 32676

    Dockweiler AG provides a wide range of tube & pipe fittings and connection components for various applications. All components are prepared for orbital welding, hygienic safe and sterile packed. Contact us for more information.
  • Product BIN / DRUM LINE

    Our line of Stainless Steel BIN and DRUM are suitable for all handling / manipulation of API and OSD, powders, liquids and viscous in pharmaceutical processes.

    Made on standard models and / or according to customer / plant construction spefications, they are durable, solid ans reliable. q...
  • Product Brachytherapy cannulas

    sfm medical devices gmbh offers wide range of products which includes brachytherapy cannulas. It belongs to oncology category. A cannula with excellent puncture values ​​was developed, adapted to the respective seed size. Contact us for more information.
  • Product Blood bag machines

    Kiefel is the market leader in the construction of machines used to manufacture blood bags. Special attention is paid to fulfilling and monitoring the highest quality criteria when manufacturing blood bags. Our innovative solutions let us offer our customers just the right level of automation to m...
  • Product Vibratory Feeding System for Tablets & Capsules

    Integrates seamlessly with Ackley printing & laser production machinery. Uses precise vibrations to convey tablets, capsules or confectionery product from one piece of equipment to the next. Crafted of stainless steel with a clear acrylic lid, this sturdy system keeps pharmaceutical and nutrac...
  • Product victory

    Get to know the unbeatable advantages of our patented, tie-bar less victory injection moulding machine series.
  • Product Continuous / Batch Tablet Coating Systems - Thomas Engineering USA

    Thomas Engineering Inc. - The Originator of Accela-Cota Tablet Coater - World's Most Advanced Tablet Coating Systems

    From fully automated, high performance tablet coating systems to small scale models, nowhere else can you find more resources and experience than at Thomas Engineering for customized ...
  • Product The new way of continuous direct compression

    The trend towards small batches continues in the manufacture of oral solids dosage forms. The Xelum platform offers continuous solutions from fluid bed granulation to direct compression. Get a presentation of our new way of continuous direct compression at CPhI in Barcelona.
  • Product prefilled syringe

    the prefilled syringe is produced by All-European machine, such as  Ambeg, BAUSCH+STROBEL, and OCMI. our annual production capacity is more than 5 millon pcs a year. the prefilled syringe is packed in nest&tub, then sterilized by the Ethylene oxide sterilization
  • Product MTG Pharmadust

    Specifically designed for conveying pharmaceutical powders. MTG Pharmadust was developed with the aim of combining the purity of materials and the safety requirements for applications in ATEX areas (ATmosphères EXplosives). The hose is certified TRGS 727, Food (FDA) and Pharma grade (USP class VI).
  • Product Batch Granulation lines

    Competence all along the line

    Whether vertical or horizontal product flow, we have the perfect solution for you!

    We offer you line concepts for batch production or continuous operation.

    As one of the pioneers and leading manufacturers of high-quality process plants with more th...
  • Product GPPI (General Processing Platform Isolator)

    The Esco General Processing Platform Isolator (GPPI) is a highly adaptable, unidirectional laminar airflow isolator that can be used for sterility testing or other processes that require an ISO Class 5 (Grade A) aseptic environment. The GPPI's advanced control system allows the operator to select either po...
  • Product ULTRA-PACTOR®

    The Ultra-Pactor® series of Roller Compactors, utilizing the same patented force controls and modified feeding system as the standard Pactor series, is designed to handle the production of high potentency products on both the Mini Pactor® and Macro Pactor®. Systems can be customized to handle produ...
  • Product Butterfly valve mcv

    American international container offers cleaning system which includes butterfly valve mcv. Feature: it is one of the best in the industry. Light weight and easy to use, manufacturers and processors around the world are relying on the müller containment valve to safeguard the health of their employees, whi...
  • Product Spiral Jet Mills series - Pilot Unit - PilotMill-6

    The PilotMill-6 jet mill is designed for product developments needs and small production campaigns, where batches from 500g to 250kg are considered. It is available in top and bottom discharge configurations, to better-fit different needs.
    The PilotMill-6 jet mill may be easily integrated in...
  • Product LGC20 roller compactor

    This machine is made of stainless steel, and the nonmetallic material which contact with powder all meet with FDA requirements. In addition, LGC20 Roller Compactor has a fully enclosed granulating system which is cleaner and more in line with GMP requirements.