Twin-screw extrusion - hot melt extrusion

Twin-screw extrusion - hot melt extrusion
Product Description

Hot melt extrusion is a commonly applied continuous technology to fabricate amorphous solid dispersions of poorly soluble drugs to enhance the dissolution and the bioavailability. The API and the polymer are getting molten due to the high shear forces and elevated temperature followed by complete homogenization of the components. When the extrudate exits the die attached to the equipment, it solidifies suddenly providing no chance for the API to crystallize. Afterward, the extrudate can be forwarded for milling e.g. with a conveying belt. With continuous extrusion, you can minimize your material cost by reducing the amount of API needed for feasibility studies.

Xedev

  • BE
  • 2016
    On CPHI since
  • 1
    Certificates
  • 1 - 24
    Employees
Company types
CMO/CDMO
Primary activities
Biopharmaceutical
Contract Manufacturer
Contract Research Organisation
Laboratory Services
Specifications
  • Selling Points
    Experienced Technicians; Quality Service

Xedev

  • BE
  • 2016
    On CPHI since
  • 1
    Certificates
  • 1 - 24
    Employees
Company types
CMO/CDMO
Primary activities
Biopharmaceutical
Contract Manufacturer
Contract Research Organisation
Laboratory Services

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