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Twin-screw extrusion - hot melt extrusion

Twin-screw extrusion - hot melt extrusion
Product Description

Hot melt extrusion is a commonly applied continuous technology to fabricate amorphous solid dispersions of poorly soluble drugs to enhance the dissolution and the bioavailability. The API and the polymer are getting molten due to the high shear forces and elevated temperature followed by complete homogenization of the components. When the extrudate exits the die attached to the equipment, it solidifies suddenly providing no chance for the API to crystallize. Afterward, the extrudate can be forwarded for milling e.g. with a conveying belt. With continuous extrusion, you can minimize your material cost by reducing the amount of API needed for feasibility studies.

Xedev

  • BE
  • 2016
    On CPHI since
  • 1
    Certificates
  • 1 - 24
    Employees
Company types
CMO/CDMO
Primary activities
Biopharmaceutical
Contract Manufacturer
Contract Research Organisation
Laboratory Services
Specifications
  • Selling Points
    Experienced Technicians; Quality Service

Xedev

  • BE
  • 2016
    On CPHI since
  • 1
    Certificates
  • 1 - 24
    Employees
Company types
CMO/CDMO
Primary activities
Biopharmaceutical
Contract Manufacturer
Contract Research Organisation
Laboratory Services

More Products from Xedev (10)

  • Spray-drying

    Product Spray-drying

    Spray-drying is an instant and continuous solvent evaporation process of a liquid feed, atomised in a heated gas, generating a final dried solidified particle.The heated drying gas moves in co-flow with the atomised feed in the process chamber where the gas transfers its heat energy to the droplets and abs...
  • Formulation and process development

    Product Formulation and process development

    Do you have an NCE that needs to be formulated in a solid dosage form or having challenging process and formulation questions, then XEDEV is your partner to assist you, as we are specialised in formulation and process development through drying, granulation, tableting and/or coating processes.

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  • Development Oral Solid Dosage forms

    Product Development Oral Solid Dosage forms

    XEDEV provides wide range of technologies going from powder to tablet in order to develop your final oral solid dosage form. • spray-drying • encapsulation • granulation (wet, dry and hot) (batch and continuous) • tableting • coating Contact us for more information.
  • Analytical package

    Product Analytical package

    XEDEV provides a broad range of analytical tools including : • Solid state analysis: mDSC, XRPD, PLM, TGA, FTIR, RAMAN • Powder characterisation : SEM, PSD (both wet and dry), flowability • Tablet characterisation : friability, disintegration, hardness, dissolution • Residual solvent determination :...
  • Fluid bed dryer/coater/agglomerator

    Product Fluid bed dryer/coater/agglomerator

    Xedev provides wide range of technologies which includes fluid bed dryer/coater/agglomerator. Contact us for more information.
  • Hot melt twin screw extruder

    Product Hot melt twin screw extruder

    Xedev provides wide range of technologies which includes hot melt twin screw extruder. Contact us for more information.
  • Perforated drum tablet/capsule coater

    Product Perforated drum tablet/capsule coater

    Xedev provides wide range of technologies which includes perforated drum tablet/capsule coater. Contact us for more information.
  • Agitated vaccum dryer

    Product Agitated vaccum dryer

    Xedev provides wide range of technologies which includes agitated vaccum dryer. Contact us for more information.
  • CDMO services - Spray-drying

    Product CDMO services - Spray-drying

    Xedev can perform the clinical production for your spray-drying project.
  • Clinical batch production

    Product Clinical batch production

    XEDEV can support clinical batch manufacturing up to Phase IIb in our clean rooms after succesfull development.

Xedev resources (1)

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