Sugammadex Sodium

Sugammadex Sodium
Product Description

To facilitate tracheal intubation, mechanical ventilation, and surgical access, NMB agents are frequently used as non-anesthetic adjuncts in surgical procedures. Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizing neuromuscular blocker, without the cardiovascular adverse effects experienced with reversal agents that directly interact with the cholinergic system. The γ-cyclodextrin has been designed to enhance binding of the guest by incorporating acidic side chains to promote an electrostatic interaction with the positive nitrogen of the blocker. Starting with γ-cyclodextrin, these side chains are readily installed by first halogenating with iodine or bromine to provide a handle for nucleophilic displacement with either 3-mercaptopropio acid methyl ester and cesium carbonate. The latter requires hydrolysis with sodium hydroxide to generate sugammadex sodium.


Sichuan Qingmu Pharmaceutical Co., Ltd

  • CN
  • 2023
    On CPHI since
  • 250 - 499
    Employees
Company types
CMO/CDMO
Generics/Biosimilars Manufacturer
Pharmaceutical company
Veterinary Company
Specifications
  • CAS Registry Number
    343306-79-6
  • Details
    Enterprise Standard established according to ChP/USP/EP

  • Selling Points
    Price; Prompt Delivery; Quality Service; New polymorph with own patent is also available
  • Model
    API
  • Supplied from
    China
  • Measured In
    kilogram

Sichuan Qingmu Pharmaceutical Co., Ltd

  • CN
  • 2023
    On CPHI since
  • 250 - 499
    Employees
Company types
CMO/CDMO
Generics/Biosimilars Manufacturer
Pharmaceutical company
Veterinary Company

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