Streptokinase E.P.

BSV Bioscience GmbH provides a wide range of biological pharmaceutical active ingredients which includes streptokinase E.P. It is a protein derived from various streptococci which combines with plasminogen to form a complex activating plasminogen into the proteolytic enzyme plasmin. It is administered intravenously, to dissolve thrombi in patients with myocardial infarction, pulmonary embolism and other thrombo-embolic occlusion of veins and arteries, usually in combination with aspirin and other anticoagulants. It is an enzyme produced by ?-hemolytic group C bacterial cells that can solve blood clots by converting plasminogen to plasmin. It is a widely used thrombolytic agent i.e. it dissolves vascular thrombi. It induces its thrombolytic effect by binding specifically and tightly to plasminogen. This induces a conformational change in the plasminogen molecule which renders it proteolytically active. It is a highly purified bacterial protein extracted from the culture filtrate of certain strains of streptococcus Group C. It is a single chain glycoprotein with a molecular weight of 45,000 – 50,000 Da and very low carbohydrate content (< 10 %). It has one major isoelectric point at pH 4.95.