Stellar Biotechnologies presents research on nanofiltration development at PepTalk Conference

The presentation reported data from the company's development and validation of filtration methods for the removal of viruses during manufacturing processes of KLH products.

The research poster presentation, titled "Development of a 20N Virus Filtration Process for Keyhole Limpet Hemocyanin (KLH) - A High Molecular Weight Protein," was authored by Stellar scientists Catherine Brisson, Laura Milbrandt, Zully Aguilar, and William Bailey. The presentation reported data from the company's development and validation of filtration methods for the removal of viruses during manufacturing processes of KLH products.

KLH is often used as a carrier molecule and active ingredient in immunotherapies or as an injectable to assess immune effects of new drugs in clinical settings. The rising use of KLH in the clinical development of new immunotherapies highlights the need for appropriate purification methods including the implementation of a robust viral clearance step into the production process. However, due to the large size and complexity of the KLH molecule, development and optimization of viral clearance can be a challenge. At PepTalk, the company presented results from its development of a nanofiltration method that demonstrated effective removal of the viruses evaluated in the study, and met suggested regulatory criteria for robustness.