Solid-State Chemistry and Pre-Formulation Research

Our Solid-State experts can help you to selectively crystallize the optimal stable form and formulate your compound. A controlled crystallization is the preferred isolation method to obtain purified material of a specific polymorphic (salt) form and crystal habit. The solid form determines the stability, solubility and permeability of the compound; therefore, the selection of a pharmaceutically suitable form will manage the risks in further development. The pre-formulation experts study excipient compatibility, pH-dependent solubility and dissolution rate optimization to improve the bioavailability. Symeres has performed hundreds of form characterization and selection screens on innovative APIs throughout the years.