Small Molecules

Small Molecules
Product Description

Our multi-patented Controlled Expansion of Supercritical Solutions (CESS®) technology enables the creation of API nanoparticles directly from solution. The process can be applied to most small molecules, with a high success rate of 80-90%.

CESS® is a bottom-up method of recrystallization that works by controlling the solubility of an API in supercritical carbon dioxide (scCO2). The use of scCO2 permits a green particle engineering process with pharmaceutical CO2 that is free from excipients and organic solvents. CESS® represents a significant improvement over previous supercritical technologies due to the employment of controlled mass transfer, flow and pressure reduction.

Benefits of CESS®

Controlled particle shape

Our nanoforming process can control the shape of particles, leading to greater uniformity.


Controlled particle size

Our technology can produce nanoparticles as small as 10 nm. Smaller particles have greater active surface areas, which permits an increased rate of dissolution.


Controlled polymorphism

Polymorphic purity tests have shown that stable single polymorphs can be produced with defined process parameters enabling polymorphic control.

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Nanoform Finland Oy

  • FI
  • 2019
    On CPHI since
  • 1
    Certificates
  • 100 - 249
    Employees
Company types
Other
View company profile

Nanoform Finland Oy

  • FI
  • 2019
    On CPHI since
  • 1
    Certificates
  • 100 - 249
    Employees
Company types
Other
View company profile

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Nanoform Finland Oy resources (1)

  • Nanoform brochure

    Brochure Nanoform brochure

    NanoImprove the Performance of Your Formulations Small and Large Molecule Formulations Across the Product Life Cycle.NanoImprove Small Molecules
    NanoImprove Large Molecules
    NanoImprove the Performance of Your BioFormulations With NanoParticles by Design
    Nanoforming Success Accelerated by Proprietary AI Technology STARMAP® Drives Predictions of NanoImprovement Success