Single B Cell Screening

Single B Cell Screening
Product Description

Biointron offers a high-throughput, fully integrated platform for accelerating antibody discovery. Biointron's high-throughput single B cell screening platform can screen 2*10^6 plasma B-cells from immunized animals. Antigen specific antibody-secreting cells can be isolated. It allows the detection of potentially rare antibodies or drugs with unique properties.

Highlights:

  • Microfluidic Technology: Microfluidic-based methods can achieve higher throughput and greater flexibility over nanowell and nanovial techniquesThis technology has been used in research with single-cell genetics, epigenetics, transcriptomics, proteomics and metabolism
  • High Efficiency: NGS sequencing & HTP mammalian Production/Validation;
  • Accelerate therapeutic development for a broad range of targets, including challenging transmembrane proteins
  • Short Timeline: Millions of cells can be screened within 1 week. By bypassing conventional hybridoma steps with single B cell screening, you can expect to gain 2-3 months.

Biointron Biological

  • US
  • 2024
    On CPHI since
  • 2
    Certificates
  • 500 - 999
    Employees
Company types
Contract Research Organisation (CRO)
Primary activities
Contract Research Organisation
Specifications
  • Details
    https://www.biointron.com/antibody-discovery/single-b-cell-screening.html

Biointron Biological

  • US
  • 2024
    On CPHI since
  • 2
    Certificates
  • 500 - 999
    Employees
Company types
Contract Research Organisation (CRO)
Primary activities
Contract Research Organisation

More Products from Biointron Biological (13)

  • Large Scale Antibody Production

    Product Large Scale Antibody Production

    Producing therapeutic antibodies or proteins in large quantities is required for many applications, including in vitro studies, in vivo animal studies, and pre-clinical trials. Biointron' s large-scale Producing services offers scaled-up production of recombinant antibodies/ proteins from hundreds of milli...
  • Small-Scale Packages-RushMab

    Product Small-Scale Packages-RushMab

    These packages are designed to offer cost-effective, time-saving solutions to meet small-scale rush needs in as fast as 8 days, with a sizable production capability for more than 5K samples.

    Now adding RushMab-Gene! With only 4 days, we can have 100ug transfection-grade expr...
  • Recombinant Protein Expression in Mammalian Cells & E. coli

    Product Recombinant Protein Expression in Mammalian Cells & E. coli

    Expression systems utilizing mammalian cells for recombinant protein manufacture introduces proper protein folding, post-translational modifications, and protein assembly, which are important for producing proteins of complete biological activity, and thus is in high demand in the therapeutic development a...
  • Abinvivo: Antibodies for In Vivo Research

    Product Abinvivo: Antibodies for In Vivo Research

    Biointron’s catalog products for in vivo research can be found at Abinvivo, where we have a wide range of: • Benchmark Positive Antibodies • Isotype Negative Antibodies • Anti-Mouse Antibodies • Bispecific Antibodies • Antibody-Drug Conjugates • Dilution Buffers
  • High-Throughput Recombinant Antibody Production

    Product High-Throughput Recombinant Antibody Production

    Biointron's high-throughput antibody production provides the most cost-effective option for recombinant antibodies, where you may choose to deliver either supernatant or purified antibodies (ug to gram level). From gene synthesis to purified antibodies (IgG, scFv, VHH, etc.), it takes as fast as 2 weeks. A...
  • VHH Antibody Discovery

    Product VHH Antibody Discovery

    SdAb or VHH is a promising next-generation therapeutic antibody technology for cancer immunotherapy and other applications. Biointron is a well-recognized leader in the field of single domain antibody discovery. Based on our advanced phage display technology and high-throughput antibody expression platform...
  • Hybridoma Sequencing

    Product Hybridoma Sequencing

    The antibody sequence is crucial for patent applications (distinguish your antibody from others), recombinant antibody expression, antibody engineering (humanization & affinity maturation), and more. Biointron offers a high-quality hybridoma sequencing service, for the sequencing of variable regions of...
  • Bispecific Antibody Production

    Product Bispecific Antibody Production

    Bispecific antibodies represent a key component of the next-generation of antibody therapy. Bispecific antibodies can target more than two different antigens at the same time. For instance, they can simultaneously bind tumor cell receptors while recruiting cytotoxic immune cells.Biointron has expressed tho...
  • Antibody Humanization

    Product Antibody Humanization

    Recombinant antibody technologies are rapidly becoming available and showing considerable clinical success. However, murine monoclonal antibodies may induce immunogenic responses, potentially limiting their application for humans. Humanized antibodies can overcome these problems and are considered to be a ...
  • Affinity Maturation

    Product Affinity Maturation

    FCMES - AM® (Full Coverage Mammalian Expression System) is Biointron's proprietary platform for affinity maturation. Each amino acid in the CDR region will be mutated to the other 18 amino acids (except Cysteine) with equal ratios. The clones will be expressed in a mammalian system and an ELISA binding ass...
  • Afucosylated Antibody Expression

    Product Afucosylated Antibody Expression

    Biointron's fucose-free host cell CHOK1BN-Fut8KO can be used for industrial production following antibody characterization and functional verification. Compared to the unmodified CHOK1BN cell line, the antibody produced by the modified cell line not only achieves afucosylation but also maintains consistenc...
  • CHO-K1 Stable Cell Line Generation

    Product CHO-K1 Stable Cell Line Generation

    Biointron provides a stable cell line development service for bioproduction purposes. Our stable cell line service, based on ECACC licensed CHO-K1 cells, aims to provide a high-yield guaranteed and speedy timeline to meet your downstream applications.

    Highlights: • High-Yield: >5 ...

Biointron Biological resources (3)

  • Webinar Webinar: Accelerating Antibody Drug Discovery with Biointron's AbDrop™ and Cyagen's HUGO-Ab™

    Biointron's latest webinar features Shun Zhou, Ph.D, the R&D Director at Cyagen: “Accelerating Antibody Discovery with Fully Human Antibody Mouse HUGO-Ab™ and Single B Cell Screening Technology AbDrop™”

    This topic explores the revolutionary potential of the genome-edited mouse HUGO-Ab, where endogenous VH and VL genes are replaced by fully human VH and VL genes in situ, enabling the generation of fully human antibody molecules. When combined with microfluidic technology-enhanced single B cell screening, this approach allows for the high-throughput and efficient discovery of antibody drug molecules.
  • Datasheet Biointron Insights: Antibody Industry Report (Q3 2024 Insights, Trends & Analysis)

    This report aims to explore the events and trends of the biopharmaceutical industry in Q3 (July, August, September).
    https://www.biointron.com/industry-trends/biointron-insights-antibody-industry-report-q3-2024-insights-trends-analysis.html

    This quarter saw an increase in research trends in higher drug–antibody ratios for antibody-drug conjugates (ADCs), with promising approaches to address the problem of high hydrophobicity. Positive results in various clinical trials for anti-TIGIT therapies have also excited the field, with safety and pharmacovigilance at the center after numerous failures. Here, we give an example of a promising monoclonal antibody in development.

    To learn more, download the trends report here: https://www.biointron.com/industry-trends/biointron-insights-antibody-industry-report-q3-2024-insights-trends-analysis.html

Frequently Viewed Together

  • Product Biologics

    End-to-end development and manufacturing capabilities across different therapeutic modalities and the entire product lifecycle

    Cutting-edge technology platforms for high yielding cell lines (both mammalian and microbial) and high concentration formulations


    Integrated and flexible drug sub...
  • Product Biologic drug substance CDMO services

    From pre-clinical development to commercial supply, Patheon by Thermo Fisher Scientific is an industry leader in the development and manufacture of mammalian cell culture drug substances. Patheon offers biotech and pharmaceutical companies the ability to pursue opportunities around the globe with a fully i...
  • Product Walk in Cooling Cabinet.

    The Walk-In Cooling Cabinets / cold rooms are designed according to ICH guidelines, WHO, MCA and USFDA requirements to maintain uniform conditions. They are superior in airflow distribution, temperature control technology, cabinet construction and are manufactured as per cGMP regulations.
    Biggest Walk...
  • Product UV Light Blocking Tyvek Equipment Covers

    UV Light Blocking Tyvek Equipment Covers are designed to keep cleaned pharmaceutical equipment and supplies clean and protected from external sources of contamination while also providing in-process protection to light sensitive biotech products.
  • Product Contract Manufacturing (CDMO/CRO/CMO)

    We are world's leading contract manufacturer.  
  • Product 1 GHz NMR

    New Evo 1 GHz NMR fits in 1 story building, uses 70% less helium. Ideally suited to characterise complex molecules such as RNA, oligonucleotides, peptides, antibodies and more!
  • Product CDMO Biopharmaceutical Production

    With an extensive offering of development services, state-of-the-art manufacturing equipment, and project support, GBI is truly a full-service CDMO biologics partner. Our approach pairs our expert knowledge base with an open mind towards scientific discovery so that together we can develop an optimal way t...
  • Product cGMP Cell-based Bioassays

    Cell-based bioassays that comply with cGMP: Using a variety of techniques, including cell-based assays, ligand and receptor binding assays, and flexible multiple assay approaches – our potency testing experts offer tailored bioassay method development, method transfer and method validation to ICH Q2 (R1)...
  • Product HANSIZHUANG (Serplulimab Injection)

    HANSIZHUANG (recombinant humanized anti-PD-1 monoclonal antibody injection, generic name: serplulimab injection) is the first anti-PD-1 mAb for the first-line treatment of SCLC and has been approved in China and Indonesia. Up to date, 4 indications are approved for marketing, 2 marketing applications a...
  • Product Biologic Quality Control and Release Testing

    We deliver responsive QC analysis for complex biologic products from our cGMP laboratories. Our scientists develop and validate methods or perform technology transfer of a sponsor's method for a wide range of analytical methods required for batch release testing. We also routinely carry out testing to Phar...
  • Product Biologics - mAbs, therapeutic proteins and ADC development

    Eurofins CDMO Alphora Inc. provides integrated solutions for small molecules, drug product, biologics and phytocannabinoids. Specializing in complex and niche small molecule drug substance and drug product services, including high potent capabilities, we provide support from preclinical to commercial devel...
  • Product Kemwell Biopharma

    SERVICES Kemwell provides integrated development and manufacturing services for companies that require one-stop solution for mammalian cell-culture based protein therapeutics The team is experienced to undertake end-to-end activities right from cell line development till cGMP clinical and commercial manufa...
  • Product Biosimilars Portfolio

    • Pegfilgrastim (Filed with EMA) • Filgrastim (Filed with EMA) • Trastuzumab (Filed with EMA, MHRA, Received recommendation for marketing authorization in India) • Bevacizumab (Filed with MHRA) • Omalizumab (Global PhIII ongoing) • Denosumab (Global PhIII ongoing) • Ranibizumab (Global PhIII ongoing...
  • Product HANLIKANG (Rituximab Injection)

    HANLIKANG (rituximab injection) is the company's first proprietary product. It is the first-ever China-manufactured biosimilar approved by the NMPA in accordance with the Technical Guideline for the Development and Evaluation of Biosimilars (Tentative) issued in 2015. As of now, HANLIKANG has bee...
  • Product Fermenters

    Fermentation is mostly extracellular activity and is brought with the help of enzymes released by the microorganisms. The Fermenter is designed to meet all process requirement for micro-organism to achieve maximum growth and productivity. Features:
    • Fully automated or semi-automated models
    • 21...
  • Product Bevacizumab

    Bevacizumab acts by selectively binding circulating VEGF, thereby inhibiting the binding of VEGF to its cell surface receptors. This inhibition leads to a reduction in microvascular growth of tumor blood vessels that limits the blood supply to tumor tissues.The indication is for Colorectal Cancer...
  • Product Epicyn

    Epicyn™ with patented technology is intended for the management and reduction of new and existing hypertrophic and keloid scars. Epicyn™ forms a protective barrier against physical, chemical and microbial invasion of the scar. It softens, flattens and reduces redness and relieves scar-associated it...
  • Product HANQUYOU(trastuzumab)

    HANQUYOU (trastuzumab, trade name: HERCESSI™ in the U.S., Zercepac® in Europe) was successfully launched in the U.S., China and Europe, becoming the Chinese mAb biosimilar entering the U.S., the EU and China market. It is indicated for the treatment of HER2 positive early breast cancer, metastatic bre...
  • Product Nimotuzumab

    Nimotuzumab binds with intermediate affinity and high specificity to the extracellular domain of EGFR and blocks the binding of the EGF to its receptor and inhibits tumor cell growth. The molecule induces cell lysis through ADCC mechanism. Nimotuzumab provides vaccinal effect that induce memory T-cell ...
  • Product Lead Discovery and design

    Abzena’s antibody discovery team collaborates with you to build the foundations of a successful program and de-risk your development path. We deliver expert assessments of target molecules, immunization strategies and antibody screening cascades that inform your selection of the best candidates for develo...
  • Product Rituximab

    Rituximab binds itself to the CD20 protein, marking them, and subsequently triggering the cells of the immune system to pick out the marked cells and kill them.The indication is for Non Hodgkin Lymphoma
  • Product HANDAYUAN (Adalimumab Injection)

    Our first product indicated for the treatment of autoimmune diseases. HANDAYUAN (adalimumab injection) was approved by the NMPA in December 2020. It is indicated for rheumatoid arthritis, ankylosing spondylitis, plaque psoriasis, uveitis, polyarticular juvenile idiopathic arthritis,  pediatric plaque ...
  • Product API-Epalrestat

    Product name: Epalrestat

    CAS NO: 82159-09-9

    Appearance: Yellow to orange red crystalline powder

    Specification: JP

    Documentation: DMF, GMP

    Application: Diabetes

    Package: 25kg/drum

  • Product Comparability Studies for Biopharmaceuticals

    We design bespoke analytical programmes that ensure that the relevant quality attributes for your drug substance or product are evaluated to support your manufacturing process changes. We select analytics referenced by the ICH Q6B to examine the product's structural features (primary, secondary and&nb...
  • Product TALMUSIN-0.4

    Tamsulosin Hydrochloride Tablets 
  • Product Netakimab

    ONetakimab – an original humanized monoclonal antibody against IL-17. Approved in Russia for plaque psoriasis. Pending approval for ankylosing spondylitis. BIOCAD will also launch an international Phase III clinical trial with the aim of approval in EU.
  • Product Rituximab

    Rituximab biosimilar, chimeric monoclonal antibody which specifically binds to the transmembrane antigen CD20. Indications: non-Hodgkin’s lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA)...
  • Product ENGINEERING

    Csv Life Science offers Conceptual, Basic and Detail Engineering services.
  • Product MabionCD20

    This is our most advanced in-house project. A MabThera/Rituxan (rituximab) biosimilar drug, whose efficacy and safety were clinically confirmed. It is the first such advanced drug developed in Poland. We are currently at the final stage of works aimed at marketing the drug in Europe and the United States.
  • Product Acarbose

    White or yellowish,amorphous powder,Hygroscopic. With GMP, DMF, CEP Certificates.
  • Product A CDMO PARTNER FOR LIFE

    FUJIFILM Diosynth Biotechnologies is an industry-leading cGMP Contract Development and Manufacturing Organization (CDMO) supporting the biopharmaceutical industry in the development and production of biologics, vaccines and cell and gene therapies. Our focus is to combine technical leadership in process d...
  • Product cGMP Protein and Antibody Purification

    KBI Biopharma has extensive experience developing purification processes for a wide variety of biotherapeutics, including: -Monoclonal antibodies-Bispecific antibodies -Enzymes -Fc fusion proteins -PEGylated proteins -Complex glycoproteins KBI supports 40+ annual programs ranging from FIH (First-in-Huma...
  • Product HANBEITAI (Bevacizumab Injection)

    HANBEITAI (generic name: bevacizumab), the fourth product independently developed by Henlius, received marketing approval from the National Medical Products Administration (NMPA) in November 2021, and its commercialization in Chinese mainland is handled by the company’s in-house team. As of now, HANBEI...
  • Product Small-Scale Packages-RushMab

    These packages are designed to offer cost-effective, time-saving solutions to meet small-scale rush needs in as fast as 8 days, with a sizable production capability for more than 5K samples.

    Now adding RushMab-Gene! With only 4 days, we can have 100ug transfection-grade expr...
  • Product Antibody Drug Conjugates (ADC)

    hen selecting AbbVie Contract Manufacturing, you are partnering with a leading developer and manufacturer focused on accelerating and mitigating risks to program timelines and on efficiently fast-tracking your program to completion. AbbVie’s mAb and ADC state-of-the-art facility and expert scientific team ...
  • Product Recombinant Protein Manufacturing Services

    Axio BioPharma is a trusted innovator and provider of high-quality recombinant proteins designed to meet the demands of the biopharma industry. Our mission is to be your preferred partner in advancing your cutting-edge biologics.

    We specialize in research-grade manufacturing of monoclonal antibo...
  • Product Hybridoma Sequencing

    The antibody sequence is crucial for patent applications (distinguish your antibody from others), recombinant antibody expression, antibody engineering (humanization & affinity maturation), and more. Biointron offers a high-quality hybridoma sequencing service, for the sequencing of variable regions of...
  • Product Rituximab

    Axxo gmbh offers biopharmaceutical products which includes rituximab. It belongs to monoclonal antibodies (mab)s products category. It is for rheumatoid arthritis, lymphoma, leukemia. Contact us for more information.
  • Product SUREmAb™

    Built on the SUREtechnology Platform, SUREmAb optimizes monoclonal antibody (mAb) development and manufacturing processes, fast-tracking the path to clinic and market. • Fast-tracked for efficiency and speed, taking you from DNA transfection to GMP drug substance in 11 months • Comprehensive mAb develop...
  • Product Antibody / Monoclonal antibody therapeutics services

    Monoclonal antibody therapeutics: We continually invest in advanced analytical instrumentation that allows us to deliver mAb analytical data with the highest degree of sensitivity, accuracy and resolution. Our experience spans recombinant monoclonal antibodies and related products such as biosimilars, ...
  • Product Brimonidne/Timolol Eye Drops

    Contact us for more information.
  • Product Protein Aggregation Analysis and Characterization

    Analysis and characterization of protein aggregates: The services provided by our experts include a range of protein aggregation analysis techniques that are used to detect and quantify aggregates in solution in support of formulation development, quality control, stability studies, comparability, rel...
  • Product Trastuzumab

    Trastuzumab binds to the extracellular domain of human epidermal growth factor receptor 2 (HER2) and inhibits HER2 homodimerization, thereby preventing HER2-mediated signaling. The indication is for HER2 Triple Positive and HER2+ Gastric Cancer / Gastroesophageal Junction cancer.

  • Product Sterile Products Contract Manufacturing

    Our main CDMO activity is the large scale manufacturing of injectable products in our internationally reputed site in Pau (France). The site is organized around 9 independent workshops, specialized in the aseptic filling under isolators of potent molecules such as anticancer cytotoxics, monoclonal ant...
  • Product Doxylag 100mg (Doxycycline) Caps

    Doxycycline, the active ingredient of Doxylag, is an antibiotic that exhibits a wide spectrum of antimicrobial activity against both Gram-positive & Gram-negative bacteria. 
  • Product High-Throughput Recombinant Antibody Production

    Biointron's high-throughput antibody production provides the most cost-effective option for recombinant antibodies, where you may choose to deliver either supernatant or purified antibodies (ug to gram level). From gene synthesis to purified antibodies (IgG, scFv, VHH, etc.), it takes as fast as 2 weeks. A...
  • Product Filgrastim (g-csf)

    Axxo gmbh offers biopharmaceutical products which includes filgrastim (g-csf). It belongs to recombinant human proteins products category. It is for post-cancer treatment. Contact us for more information.
  • Product 3BNC117 - A Novel Broad-spectrum HIV Neutralizing Antibody

    3BNC117 is one of the most effective broad-spectrum HIV neutralizing antibodies. Several phase 1 and phase 2 clinical trials have been conducted in the US, showing 3BNC117 not only blocks viral replication like other AIDS drugs, but also induces immune response to HIV and HIV-infected cells. Combining 3...
  • Product VHH Antibody Discovery

    SdAb or VHH is a promising next-generation therapeutic antibody technology for cancer immunotherapy and other applications. Biointron is a well-recognized leader in the field of single domain antibody discovery. Based on our advanced phage display technology and high-throughput antibody expression platform...
  • Product Protein Therapeutic Glycosylation Studies

    In line with ICH Q6B, we deliver glycosylation analysis for proteins, antibodies, bispecifics including assessment of the glycosylation site, carbohydrate content and glycan structure. With a range of MS approaches, our protein characterisation scientists provide detailed glycosylation studies designed to ...