Researchers develop oral delivery of siRNA

The many possible solutions to delivering siRNA has been the subject of much of Fierce Drug Delivery's reporting.

We have reported many times on both the promise and the problems associated small interfering RNA (siRNA). They can "silence" genes that cause specific diseases. That’s the promise. The problem? Getting the tiny strands exactly where they need to go without doing unintended harm. The many possible solutions to delivering siRNA has been the subject of much of Fierce Drug Delivery's reporting.

Researchers at the Georgia Institute of Technology and Emory University have come up with an siRNA delivery method that is so simple it could come under one of those why didn’t I think of that?" categories. Their siRNA drug-delivery solution? Swallow them.

Turns out, "delivering" siRNA directly into the stomach could potentially treat inflammatory bowel diseases. What has to happen first, though, is there needs to be some kind of protective covering over the siRNA strands that not only protect the digestive system from harm but also contain just the right chemistry to deliver s