Protein Aggregation Analysis and Characterization

Analysis and characterization of protein aggregates: The services provided by our experts include a range of protein aggregation analysis techniques that are used to detect and quantify aggregates in solution in support of formulation development, quality control, stability studies, comparability, release testing and aggregation studies. We can conduct aggregation analysis in accordance with the requirements of the ICH Q6B guideline, offering studies to either Good Laboratory Practice (GLP) or Good Manufacturing Practice (GMP).

• Analytical ultracentrifugation (AUC)
• Size exclusion chromatography (SEC, SEC-MALS)
• Dynamic light scattering (DLS)
• Light obscuration Zeta potential
• Capillary electrophoresis CE (CZE, MECC, Gel CE, cIEF/iCIEF)
• Gel electrophoresis (Native, SDS-PAGE, IEF)
• Electron microscopy (TEM and SEM)
• Circular dichroism (CD)