Products for Drug Delivery Systems (PEG, Lipid, Polysorbate 80)

We manufacture high-purity methoxy-polyethylene glycols (mPEGs) with molecular weights from 2 kDa to 80 kDa, producing high-purity activated PEG derivatives of methoxy PEG amines, maleimides and carboxylic acids. Various alterations of the terminal PEG chemistry permit drug modification as per customers’ expectations and needs. Recently, we have developed high purity monodisperse PEGs especially for Antibody Drug Conjugates (ADCs) to increase hydrophilicity and payload of drugs. In early 1990’s, we commenced supply of GMPgrade phospholipids to every corner of the world. Our products have been used in commercialized liposomal drugs for anti-fungal and oncology use, which led to our outstanding reputation in this field. Furthermore, use of PEGylated phospholipids composed of our high-purity phospholipids and PEGs prolongs the plasma circulating half-life of liposome drugs. For the benefit of our customers, we have also developed high-purity cationic lipids, diacylglycerol- PEGs and novel SS-cleavable/pH-responsive lipids for effective Lipid Nanoparticle (LNP) delivery of gene, nucleic acids and small molecule. Our polysorbate, Polysorbate 80 (HX2)™, is used as ultrapure surfactants, and we are proud that it is well-known around the world to have super high quality. Polysorbate 80 (HX2)™ has fewer impurities compared to conventional grade products. Polysorbate 80 (HX2)™ features low impurities and low susceptibility to oxidation thereby contain negligible amounts of peroxides and aldehydes, which are well-known to induce degradation of drug formulations. Polysorbate 80 (HX2)™ also shows superior safety features, including a lower incidence of allergic, hemolytic, cytotoxic and acute toxicity reactions compared to conventional grade products.