Plasdone™ povidone

Blanose™ CMC are anionic, water-soluble cellulose ethers, produced by reacting alkalicellulose with monochloroacetic acid under controlled conditions. Blanose™ CMC is available in a variety of grades with different degrees of substitution,viscosity and particle size to meet specific formulation requirement...

The molecular structure of cyclodextrins creates a bucket-like cavity that can complex with molecules or functional groups on molecules to improve solubility of poorly soluble compounds. The same mechanism makes these excipients capable of masking unpleasant taste/odor and stabilizing drugs that are prone ...

cavitron™ cyclodextrins (hydroxypropyl betacyclodextrin) are the perfect substances for increasing solubility and enhancing bioavailability. They are manufactured to high purity standards for low bioburden and endotoxin.
To learn more visit https://www.ashland.com/industries/pharmaceutical/oral-...

Ferronyl™ iron supplement isan ideal source of essentially pure iron with low toxicity,minimal metallic taste andexcellent bioavailability. Ferronyl™ iron supplement is elemental iron (Fe) with high (> 98%) iron content,manufactured by the chemical decomposition of iron pentacarbonyl. The resulting iron...

Natrosol™ 250 hydroxyethylcellulose (HEC) is a nonionic, water-soluble cellulose ether. Natrosol™ 250 HEC is easily dispersed in cold or hot water to give solutions of varying viscosities and desired properties, though it is insoluble in organic solvents. It is used in solutions and gels to control rheolog...

Pharmasolve™ N-methyl-2-pyrrolidone (NMP) is a versatile solubilizer for one-component systems. It is a water-miscible polar aprotic solvent with high interfacial activity. Pharmasolve™ NMP is manufactured in a facility with ISO 9001:2015 and EXCiPACT GMP certifications. It is used as a drug solubilizer an...

Plasdone™ S-630 copovidone is a 60:40 random, linear copolymer produced by the free radical polymerization of N-vinyl-2-pyrollidone and vinyl acetate. The pyrrolidone ring is responsible for excellent water solubility, adhesion, film forming and solubilization properties, while the vinyl acetate monom...

Polyplasdone™ crospovidone superdisintegrants are synthetic, insoluble, but rapidly swellable, crosslinked homopolymers of N-vinyl-2-pyrrolidone. Crospovidone provides rapid disintegration and dissolution to oral solid dosage forms. Polyplasdone crospovidone particles are granular and porous compared ...

PVP Iodine complex kills microorganisms on contact, is safer and easier to use than classic iodine preparations and has low systemic toxicity. In addition, it forms films that protect open wounds. Because it is soluble in water as well as in organic solvents, it an be formulated in powders, tablets, lozeng...

benecel™ hypromellose (hydroxypropyl-methylcellulose or HPMC) is a versatile excipient with a variety of applications. HPMC is the most widely used polymer in hydrophilic matrix systems with widespread use in controlled-release dosage forms.
benecel™ DC HPMC is a surface modified, co-proce...

Klucel™ Xtend HPC extended release matrix former is the new product in the Klucel™ line, offering unsurpassed process versatility and release profile efficiency. This step change product has been shown to match the release profile of widely used hypromellose controlled-release formulations with half the po...

vialose™ trehalose dihydrate is a premier performance sugar that is resistant to acid hydrolysis and enzymatic cleavage. It is used to protect and shield biologic APIs, recombinant proteins, and monoclonal antibodies (mAbs) from degradation and aggregation and to stabilize and protect valuable componen...

WILMINGTON, Del., Oct. 31, 2022 (GLOBE NEWSWIRE) announced the United States Food and Drug Administration (FDA) Center for Drug Evaluation and Research Office of New Drugs has accepted Ashland Viatel™ bioresorbable mPEG-PDLLA pharmaceutical excipient in the review cycle of the FDA Novel Excipient Review Pilot Program.

This session was originally broadcast as part of the CPHI Worldwide 2021 digital content programme. The session discusses: Challenges faced when removing TiO2 from film coatings Aquarius TM TF. A reliable and effective alternative to TiO2 in film coatings Improved process economics with Aquarius Genesis TF high-solids TiO2-free film coating

Wilmington, Del., Oct. 3, 2022 - Ashland is introducing Klucel™ xtend hydroxypropyl cellulose (HPC) controlled release matrix former, designed to deliver unsurpassed process versatility and release profile efficiency. 
Until now, there were limited options for managing the release profile of formulations, especially high dose, controlled release formulations. Ashland’s step change klucel™ xtend HPC has been shown to match the release profile of hypromellose controlled-release formulations at half the polymer concentration. The highly reduced polymer concentration achievable with klucel™ xtend HPC offers the possibility of smaller pills or higher dosage, if necessary. This new excipient offers unrivaled versatility across a broad range of APIs in every manufacturing process: dry granulation, wet-granulation, direct compression, and holt-melt extrusion.

Hydrophilic polymer matrix systems are widely used in oral controlled drug delivery because of their flexibility to obtain a desirable drug release profile, cost effectiveness, and broad regulatory acceptance.

Hydroxypropyl methyl cellulose (HPMC) is the key matrix former used in the majority of formulations. As controlled release formulations continue to evolve, so does the need for more robust and flexible matrix forming polymers. Join this learning lab session to:
understand key mechanistic aspects of hypromellose-enabled hydrophilic matrix tablets discover how polymer engineering results in optimized Benecel HPMC grades (new Benecel XR & XRF HPMC grades) learn about the advantages of Benecel DC Hypromellose in flow and loss-in-weight (LIW) feeding for continuous manufacturing compared to regular HPMC grades



Click here to register

Wilmington, Del., June 20, 2023 - Ashland is introducing Polyplasdone™ Plus, a co-processed multifunctional direct compression superdisintegrant containing a glidant and lubricant. Saving time and simplifying development, the multifunctional disintegrant offers superior powder flow and lubrication during pharmaceutical manufacturing. This innovative product eliminates two manufacturing steps and simplifies equipment setup while simultaneously delivering improved tablet hardness and helping ensure the production of consistent, high-quality products in batch and continuous manufacturing.

Ashland offers a range of excipients and technologies, polymer expertise, and technical support for oral solids, liquids, and parenteral dosage forms. Our solutions include controlled release, binders, disintegrants, solubles, stabilizers, rheology modifiers, and resorbable polymers.

Ashland has raised the bar on its business-driven environment, social and governance (ESG) targets by demonstrating a clear link between its long-range strategic plans and detailed ESG progress.