Comparative Study: Low-Volume Mixing Performance on Protein Formulation Shear Stress

In biologics production, mixing operations are crucial for maintaining fluid homogeneity. However, shear stress during mixing can affect protein stability and quality attributes. Understanding how mixer design and process parameters influence shear force generation is essential for product integrity.

Computational Fluid Dynamic (CFD) modeling during product development demonstrated that the Mixed4Sure™ Bottom Mount impeller design outperformed traditional stir bars. Subsequent laboratory evaluation using lysozyme as a protein model confirmed these findings.

This session will highlight the importance of innovative mixer designs in optimizing protein formulation processes that will help you maintain product quality. During the session, the following key takeaways will be discussed:

• CFD modeling revealed superior mixing performance of the new impeller geometry
• Laboratory studies validated the CFD predictions
• The Mixed4Sure™ Bottom Mount demonstrated lower shear stress compared to conventional stir bars, indicating improved mixing performance in shear sensitive process steps.