OMT Announces Novel Human Antibody Platform
Open Monoclonal Technology, Inc. (OMT) today announced its new human antibody platform using the first genetically engineered rats expressing a human antibody repertoire.
First genetically engineered rats expressing human antibodies
PALO ALTO, Calif.--(BUSINESS WIRE<http://www.businesswire.com>)-- Open Monoclonal Technology, Inc. (OMT) today announced its new human antibody platform using the first genetically engineered rats expressing a human antibody repertoire. The company, which also created the first targeted knockout rats in 2009, is now cross-breeding the knockout animals with the rats expressing human antibodies to finalize its platform.
“Creating rats expressing human antibodies was the final milestone in the development of OMT’s platform,” said founder and CEO Dr. Roland Buelow, at the IBC Annual Antibody Engineering Conference in San Diego. “Expression of a human antibody repertoire in genetically engineered animals requires two steps: the inactivation of endogenous rat antibody expression and the introduction of fun
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