NeuroDerm issued a new US patent for aqueous apomorphine covering concentrated subcutaneously delivered pharmaceutical compositions

NeuroDerm has announced that the US Patent and Trademark Office has issued US Patent No. 9,381,249, which claims aqueous pharmaceutical compositions comprising apomorphine, and relates to the company’s ND0701 program. ND0701's formulation, containing concentrated apomorphine-base, is intended for chronic therapy of Parkinson's disease and is developed for continuous subcutaneous administration by a small, low-volume, disposable patch-pump. ND0701 has been shown in pre-clinical studies to have better local tolerability than commercially available, continuous, subcutaneously administered apomorphine-HCl. NeuroDerm is currently conducting a bioequivalence trial in the EU (Trial 101) comparing ND0701 with commercially available continuous, subcutaneously delivered apomorphine-HCl in its pursuit of a regulatory development route in the EU based on bioequivalence. The patent has an expiration date of 2033.