Merck & Intercell End MRSA Vax-Trial
The decision to terminate was based on the observation that V710 was unlikely to demonstrate a statistically significant clinical benefit.
Merck & Co. and Intercell AG said Wednesday they have ended the Phase II/III trial investigating Staphylococcus aureus vaccine, V710, following analysis of the trial data and the unanimous recommendation by an independent Data Monitoring Committee (DMC).
The DMC informed Merck that the trial had not met the formal futility criteria but recommended that enrollment in the trial be suspended pending additional analyses of the benefits and risks of vaccination.
The decision to terminate was based on the observation that V710 was unlikely to demonstrate a statistically significant clinical benefit, as well as a safety concern regarding overall mortality and multi-organ dysfunction that occurred with greater fre
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