MALDI-TOF MS techniques in microbial identification
MALDI-TOF MS is a highly sensitive, cost-effective, and fast method for identification of bacterial, viral and fungal species. Its applications continuously expand but the most important one is rapid microorganism detection in pharmaceutical industry.
The technique analyzes ribosomal proteins unique to specific microorganisms by creating a mass spectrum “fingerprint” compared against a database for identification. This allows for the identification of up to 96 isolates in just 1.5 hours.
While highly effective, the technique faces challenges such as smaller library spectra for environmental strains and the need for improved databases and sample preparation methods. Despite these challenges, MALDI-TOF MS remains a promising tool for various microbiological applications due to its speed, precision, and cost-efficiency.
Identification of microorganisms based on MALDI-TOF MS method has found application in numerous laboratories and industries. This technique is fast, precise and relatively inexpensive. Thanks to its multi-level functionality, it can successfully serve as an alternative to more traditional microbial identification tools. The ability of MALDI-TOF MS to accurately and rapidly detect potential threats enables efficient responses and helps maintain a high level of microbiological safety.
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