Major boost for combatting drug addiction in Scotland as SMC gives green light to new wafer-thin treatment

Espranor represents the first major advance available in opioid substitution therapy for 10 years.

“For many of us the current drug problem needs new solutions, one of which is a bigger range of opiates and modalities of delivery than is currently available for medical assisted treatment. Espranor is a significant advance in extending the management of opiate drug problems in its ability to dramatically reduce supervision time allowing, or eliminating, some of the limiting factors in daily management in communities and custody situations,” said Roy Robertson, a GP in Edinburgh, Professor of Addiction Medicine at Edinburgh University and Chair of the Scottish Government group on Harm Reduction. “Espranor has the potential to extend treatment to a large group and to draw in those currently not in supportive treatment. This could be a serious advantage in our attempts to limit the damage and prevent the alarming rate of drug related deaths.” The majority of people in Scotland accessing opioid substitution therapy are treated with methadone and just over 15% receive buprenorphine or buprenorphine and naloxone. Licenced buprenorphine is currently in the form of a compressed sublingual tablet which usually takes between 5 and 10 minutes to dissolve and carries the risk of diversion and misuse. As a result of this patients may experience close supervision throughout their treatment and this lengthy supervised self-administration procedures are often regarded as humiliating and such stigma presents a barrier to buprenorphine uptake. Current treatments still fail many patients, with approximately 50% of patients dropping out of both buprenorphine and methadone maintenance treatment within 6 months.

“Combating opioid addiction is a huge issue in Scotland and today’s announcement is great news for patients who want to be treated for their addiction but are failing on their current treatment,” said Annemarie Ward, CEO of Faces and Voices of Recovery. “Having another choice of treatment available is always a cause for celebration and now being able to offer a simpler form of buprenorphine, we may increase its use and reduce some of the problems seen with conventional pills.”

Recently published data on Espranor show that, when compared with current hard sublingual (under the tongue) tablets, the novel formulation dissolved quickly with no increased respiratory safety risk or concerns and no significant difference in efficacy.