LIPEX® Liposome Extruders

Evonik’s platform of LIPEX® liposome extruders have set the industry standard for liposomal drug product manufacturing for almost 30 years. LIPEX® liposome extruders are widely used across the pharmaceutical and biotechnology industry to create homogeneous populations without the need for solvents or detergents. A one-step process forces aqueous suspensions of lipids through filters with a defined pore size. Unlike some alternative technologies, the relatively gentle pressures at controlled temperatures to which the formulations are exposed ensure optimal particle size reduction and high trapping efficiency. To provide an integrated scale-up process from drug discovery through to GMP production, a range of our products are available from Evonik in lab, pilot, intermediate and commercial-scale volumes. In addition to others, Evonik also offers a range of other technology solutions for liposome manufacturing including microfluidics.