Purolite resin portfolio for immobilized enzymes

In the Day in the Life of Series, we've already had the chance to get to know a range of people in various roles in the pharma industry. In the latest interview we get a glimpse into the R&D side of things from Jennifer Sorrells, Vice President Research Development & Engineering Global Life Sciences, Ecolab. 

The Praesto® range includes a selection of affinity chromatography and ion exchange chromatography agarose resins, delivering exceptional results from capture to high-resolution polishing steps.  All Praesto® products provide an advanced, high-flow, highly cross-linked agarose base matrix, and are available in a range of formats to suit your process needs, from high throughput to full-scale commercial manufacture. 

Looks at the benefits of jetted uniform size beads versus traditional batch emulsification production.

Answers questions that customers have when discussing PuroMill Pharmaceutical Grade Milling Media. The media is used to create nanoparticles < 100 nm to support small-molecule formulation development and increase solubility in and bioavailability of poorly soluble compounds. The media is composed on small polymer beads and is produced in a cGMP facility. There is a DMF on file wth the U.S. FDA.

Provides an overview of highly purified PuroMill polymeric milling media, which enables solubility enhancement of small molecules through the creation of nanoparticles < 100 nm. The media can be used in formulation development of all dosage forms. The media is manufactured in a cGMP facility and has a DMF filed with the U.S. FDA.

Presents an overview of Chromalite® Synthetic Resins, PuroPhase™ SPE Reverse Phase Resins, Lifetech™ Enzyme Carriers and Ready-to-Use Immobilized Enzymes, Praesto® Agarose Resins, PuroSynth™ Resins for Solid-Phase Peptide Synthesis (SPPS), Purolite® Pharmaceutical APIs and Excipients, and PuroMill® Polymeric Media for High-Speed Milling.

Presents an overview of Purolite API and Excipient products, including Sodium Polystyrene Sulfonate, Calcium Polystyrene Sulfonate, Cholestyramine, Polacrilex and Polacrilin Potassium. 

Highlights the use of ion exchange resins and polymeric adsorbents in a variety of pharmaceutical and biotechnology applications. 

Reviews a number of Purolite adsorbents, which are available in a broad range of matrices and porosities for applications including adsorption in pharmaceutical production, size exclusion chromatography for inorganic salts, enzyme immobilization, polyphenol removal and more. 

This brochure provides information on PuroSynth™ supports for Solid Phase Peptide Synthesis (SPPS) made of polystyrene crosslinked with 1% DVB, characterized by uniform particle size distribution, high swelling and excellent performance in peptide synthesis.

Reviews the CalB immo KIT, which includes a range of preparations of lipase B from Candida antarctica (CalB) immobilized on 6 different Purolite Lifetech™ ECR resins that are specifically designed to support scientists in development new processes by facilitating rapid product screening.

CalB immo Plus™, a high-performance and highly hydrophobic immonilized CalB preparation, has been produced through a joint development and manufacturing collaboration between Purolite and c-LEcta. This brochure looks at using lipase B from Candida antarctica in biocatalysis applications, such as the production of cosmetic additives for personal acre, active pharmaceutical ingredients and food ingredients.

Lifetech™ ECR resins are robust enzyme carriers designed for research and industrial applications. This guide provides step-by-step immobilization protocols for Lifetech ECR epoxy resins, Lifetech ECR amino resins, Lifetech ECR, adsorbents and Lifetech ECR enzyme carriers for ionic immobilization. The guide also presents helpful information on selecting, working with and testing immobilized enzymes.

Immobilized enzymes are robust catalytic agents that enable easy separation of the enzyme from the product as well as reuse of the enzyme. They are also powerful tools for optimizing process operations.This product information guide reviews the Purolite Lifetech™ portfolio of resins for covalent, adsorption and ionic immobilization for pharmaceutical, biopharmaceutical and chemical applications.

This product information guide presents an overview of the advantages of Purolite’s Chromalite® polymeric resins over silica for the purification of biomolecules in reverse-phase chromatography. Covers an overview of Purolite's product line, the use of different resins for different applications, the advantages over silica, characteristic of the resin, applications, packing procedures and more. 

This product information guide presents an overview of Chromalite® CGA and CGC chromatographic ion exchange resins for small organic and inorganic compound separation and purification.

Presents advantages and product characteristics of Purolite's new robust, hydrophilic, porous methacrylic chromatographic resins for the chromatographic purification of peptides, oligonucleotides, proteins, enzymes and biomolecules up to 500kDa.

This guide presents information on packed solutions containing Lifetech™ ECR and immobilized enzymes, allowing easy and fast screening and optimization of biocatalyzed processes. Covers information in SpinChem magRBR and suggested applications and usage such as immobilization protocols, effects of wedding before immobilization, recycling studies and effect of mass transfer. 

Purolite® Life Sciences has revolutionized the future of Protein A chromatography with Praesto® Jetted A50 by combining ‘Jetting’ technology - an innovative process that produces uniform size agarose beads with a very narrow particle size distribution - together with a new, high performance Protein A ligand, NGL-Impact™ A, from Repligen® Corporation. This brochure provides product specifications and characteristics, as well as technical information. 

Provides product characteristics, specifications and engineering data for these 35µm uniform particle size agarose beads for the purification of recombinant proteins and monoclonal antibodies.

Provides a comprehensive product overview for Praesto® agarose chromatography resins, including Protein A resins such as Praesto APc & Praesto AP, and Praesto AC, and Praesto ion exchange resins such as Praesto Jetted 35µm, Praesto® SSP and Praesto Q, base matrices such as Praesto Pure, and Pre-Activated resins such as Praesto CNBr, Praesto Epoxy and Praesto NHS.  Prepacked formats are also reviewed such as Praesto HT Columns, Praesto RoboColumns®, Praesto MiniChrom Columns. 

Reviews technical and product specifications and process economics for Praesto® Apc, Praesto® AP, and Praesto® AC resins.

Covers product specifications, characteristics, engineering data and application information for Praesto® Jetted 35, Praesto®  SP and  Praesto®  Q resins. 

Presents an overview of Purolite Corporation with a focus on the products, people and mission of Purolite Life Sciences.