Intellikine Launches INK1117 Phase I Study
The Phase I study is to evaluate the safety, tolerability and pharmacokinetic profile of INK1117 in patients with advanced solid malignancies.
Biotherapeutics company Intellikine has initiated a multicentre Phase I dose escalation study of INK1117, a selective, orally available, small molecule inhibitor of the PI3Kalpha isoform, in patients with advanced solid malignancies.
The Phase I study is to evaluate the safety, tolerability and pharmacokinetic profile of the PI3Kalpha selective inhibitor.
In PI3Kalpha mutant-specific preclinical tumour models, INK1117 has demonstrated good efficacy results.
INK1117 will be explored in cancer patients, particularly those whose tumours have a mutation of the PIK3CA gene.
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