Solv4U

Marinosolv® - A Novel Approach to Increase the Solubility and Improve the Bioavailability of Promising Low-Soluble Drugs

80-90% of promising, highly potent drug candidates in the R&D pipeline fail due to their low solubility in aqueous formulations, and subsequently their low bioavailability.The solubility of a drug in aqueous formulations is a critical factor for the permeability and thereby bioavailability and systemic absorption into sensitive target tissues and/or at the site of action. Therefore, several different chemical and physical approaches to increase the solubility of a drug in aqueous formulations have become available in the last decade. One of them is Marinosolv®, a formulation technology that provides effective solubilization for a variety of highly hydrophobic small molecules and peptides, including APIs/NCEs.