I Holland Offers an Answer to Tablet Tooling Degradation With a Combination of Solutions
Wear and deterioration of tooling is unavoidable in tablet manufacture, but it can be reduced significantly by using the correct tooling materials and coatings. Leading global tablet tooling manufacturer, I Holland, has researched the science behind this complex issue and offers a number of solutions to extend the life of punches and dies.
I Hollands R&D Manager, Rob Blanchard said: "Deterioration of tablet tooling is inevitable and is a problem that leads to other tablet-making problems, including adherence of the granules because of the pitted and worn surfaces of the punches and also capping or lamination of the tablets. I Holland has studied these issues and have a comprehensive offering of materials and coating solutions to eliminate this common problem.
High quality tooling should be able to offer a long life and be anti-abrasive and wear resistant. To achieve this there are several options. We have introduced PharmaGrade, a range of raw materials, that have been developed and tested to ensure todays tooling requirements are encompassed. The PharmaGrade range incorporates several wear-resistant materials including HPG-P (Holland PharmaGrade Premium), a high quality ESR grade punch and die material, HPG-MP and HPG-MD (Holland PharmaGrade Powder Metallurgy Punches/Dies), specialised powder metallurgy grade steels with uniform carbide distribution and small carbide size offering extremely high wear resistance; and HPG-TC, a sintered micro grained tungsten carbide cemented with cobalt, which has extremely high wear resistance and is great for preventing die bore ringing. Blanchard comments; Tungsten carbide is often used for the dies to prevent wear and deformation of the die bores. It features a high compressive strength with an extremely high wear resistance. This helps to reduce die bore wear and ringing and lasts longer than conventional die steels.
The other important consideration is to use enhanced coatings and treatments. The I Holland PharmaCote range includes several coating options to increase tooling life. PharmaCote RS, is just one of the products that has been specifically developed to combat abrasion This is an extremely hard coating at 3000Hv, almost three times as hard as Hard Chromium. It offers excellent wear resistance. One customer reported increasing tablet output by 900% from one set of tools due to the application of this coating.
Tablet tooling has to combine complex design and functional requirements to ensure productivity and durability are at their maximum in manufacture. To follow this important process, the introduction of products including PharmaGrade and PharmaCote, offers a solution to tablet punch and die wear.
Related News
-
News US BIOSECURE Act passed by US House of Representatives
The controversial act, which has already impacted several foreign companies operating in the US, was passed by the House of Representatives on September 9, 2024. It is now headed for the US Senate before it can be signed into law by President Joe Biden... -
News Pharma Supply Chain People Moves
The latest appointments, promotions, and structural changes across the pharmaceutical supply chain. -
News Drug prices agreed upon as part of the US Inflation Reduction Act
The Inflation Reduction Act brought into constitution by the Biden administation in 2022, which proposed a drug price negotiation between the government and pharmaceutical companies, has reached it's first agreement. -
News BIOSECURE Act continues to loom over Chinese pharma manufacturers
With the US BIOSECURE Act on its way to passing into legislation, Chinese companies are facing declining revenues within the first half of 2024 as US pharmaceutical and healthcare companies pull their businesses from the country. -
News Ophthalmologic drug product Eylea faces biosimilar threats after FDA approvals
Regeneron Pharmaceutical’s blockbuster ophthalmology drug Eylea is facing biosimilar competition as the US FDA approves Biocon’s Yesafili and Samsung Bioepis/Biogen’s Opuviz. -
News ONO Pharmaceutical expands oncology portfolio with acquisition of Deciphera
ONO Pharmaceutical, out of Japan, is in the process of acquiring cancer-therapy maker Deciphera Pharmaceuticals for US$2.4 billion. -
News First offers for pharma from Medicare drug price negotiations
Ten high-cost drugs from various pharma manufacturers are in pricing negotiations in a first-ever for the US Medicare program. President Biden’s administration stated they have responded to the first round of offers. -
News Eli Lilly’s Zepbound makes leaps and bounds in weight-loss drug market
In the last week, Eli Lilly has announced their partnership with Amazon.com’s pharmacy unit to deliver prescriptions of Zepbound. Zepbound has also surpassed Novo Nordisk’s Wegovy for the number of prescriptions for the week of March 8.&nbs...
Position your company at the heart of the global Pharma industry with a CPHI Online membership
-
Your products and solutions visible to thousands of visitors within the largest Pharma marketplace
-
Generate high-quality, engaged leads for your business, all year round
-
Promote your business as the industry’s thought-leader by hosting your reports, brochures and videos within your profile
-
Your company’s profile boosted at all participating CPHI events
-
An easy-to-use platform with a detailed dashboard showing your leads and performance