High-potency monoclonal antibody therapeutics find application scope in precision medicine
![](/46/pdcnewsitem/03/80/47/Frost.jpg)
Technology convergence through partnerships, mergers and acquisitions is yielding a stream of strong candidates, finds Frost & Sullivan.
Next-generation monoclonal antibody-based platforms are gaining momentum and expected to impact patient care, particularly in the field of precision medicine. Antibody therapeutics are evidencing continuous evolution over time, especially in terms of its potency against disease targets, ability to treat more than one aspect of a disease simultaneously, enhanced and less expensive production processes as well as fewer side effects.
New analysis from Frost & Sullivan, Advances in Monoclonal Antibody Therapeutics, finds monoclonal antibody therapeutics have received extensive attention in the past two decades. Currently, there are 50 monoclonal antibody drugs in the market and the competition among large biopharmaceutical companies is aggressive. More than 500 companies populate this space, developing novel discovery platforms and bioinformatics resources, among other products. In addition, contract manufacturing companies are becoming increasingly popular. Overall, the global monoclonal antibody therapeutics market expects to expand at a compound annual growth rate of 8.1% during 2014 through 2020.
Monoclonal antibody therapeutics are being used for the treatment of a wide variety of diseases, especially in the following areas:
The development of new molecular agents with high specificity is playing a crucial role in the growth of the pharmaceuticals industry.
“Efforts to create advanced molecular agents indicate the top biopharmaceutical companies’ strong focus on biologics,” said TechVision Industry Analyst Cecilia Van Cauwenberghe. “However, during cell line generation, which is an important part of the molecular agent development process, it will be challenging to ensure the optimization of the cell expression system to increase capacity.”
On the other hand, the approval of biologics may affect competing therapeutics. A significant concern for the competition is the cost of developing and producing biologics is remarkably higher than conventional small molecule medications. Furthermore, there is a need for investments in biologics infrastructure and manufacturing.
Big pharmaceutical companies are advancing through potentially lucrative deals to acquire antibody technologies, compensating for patent losses in traditional molecules and making it easier to tackle the advent of biosimilars. They are resorting to mergers and acquisitions as well as partnership and collaboration activities with top-tier players, highly innovative small and medium-sized biotech companies, governmental institutions and leader venture capitals to gain access to the latest developments in monoclonal antibody therapeutics.
“Partnership deals and agreements are adding impetus to technology synergy,” concluded Van Cauwenberghe. “As a result, high-potency products such as ultrapotent antibodies obtained by replacing amino acids, bispecific antibodies and antibody fragments, as well as, glycoengineered antibodies and other innovative solutions are gaining increasing attention.”
Advances in Monoclonal Antibody Therapeutics, a part of the TechVision subscription, provides expert opinions on the emerging trends in monoclonal antibody therapeutics globally, through a detailed strategic assessment of the industry environment.
Frost & Sullivan's global TechVision practice is focused on innovation, disruption and convergence and provides a variety of technology based alerts, newsletters and research services as well as growth consulting services. Its premier offering, the TechVision program, identifies and evaluates the most valuable emerging and disruptive technologies enabling products with near-term potential. A unique feature of the TechVision program is an annual selection of 50 technologies that can generate convergence scenarios, possibly disrupt the innovation landscape, and drive transformational growth.
Related News
-
News Ophthalmologic drug product Eylea faces biosimilar threats after FDA approvals
Regeneron Pharmaceutical’s blockbuster ophthalmology drug Eylea is facing biosimilar competition as the US FDA approves Biocon’s Yesafili and Samsung Bioepis/Biogen’s Opuviz. -
News ONO Pharmaceutical expands oncology portfolio with acquisition of Deciphera
ONO Pharmaceutical, out of Japan, is in the process of acquiring cancer-therapy maker Deciphera Pharmaceuticals for US$2.4 billion. -
News First offers for pharma from Medicare drug price negotiations
Ten high-cost drugs from various pharma manufacturers are in pricing negotiations in a first-ever for the US Medicare program. President Biden’s administration stated they have responded to the first round of offers. -
News Eli Lilly’s Zepbound makes leaps and bounds in weight-loss drug market
In the last week, Eli Lilly has announced their partnership with Amazon.com’s pharmacy unit to deliver prescriptions of Zepbound. Zepbound has also surpassed Novo Nordisk’s Wegovy for the number of prescriptions for the week of March 8.&nbs... -
News Chasing new frontiers at LEAP – The National Biotechnology Strategy Keynote
On the third day of LEAP (4–7 March 2024, Riyadh Exhibition and Convention Centre, Malham, Saudi Arabia) the CPHI Middle East team hosted the Future Pharma Forum, to set the scene for an exciting new event for the pharma community, coming to Riya... -
News Pfizer maps out plans for developing new oncology therapeutics by 2030
Pfizer dilvulges plans to investors around growing their cancer portfolio, and the drugs they will be focusing on developing after their aquisition of Seagen in 2023. -
News Generics threat to Merck’s Bridion as Hikma seeks pre-patent expiry approval
Merck has disclosed they received notice from Hikma Pharmaceuticals for seeking a pre-patent expiry US FDA approval for Hikma’s generic version of Merck’s Bridion. -
News Bernie Sanders vs Big Pharma - the latest on drug price negotiations
In a hearing in front of the US Senate, three of the biggest pharmaceutical companies in America are challenged over exorbitant prescription drug prices, with Sanders claiming their actions are limiting the population's access to affordable healthc...
Position your company at the heart of the global Pharma industry with a CPHI Online membership
-
Your products and solutions visible to thousands of visitors within the largest Pharma marketplace
-
Generate high-quality, engaged leads for your business, all year round
-
Promote your business as the industry’s thought-leader by hosting your reports, brochures and videos within your profile
-
Your company’s profile boosted at all participating CPHI events
-
An easy-to-use platform with a detailed dashboard showing your leads and performance