HemoShear Therapeutics announces next stage of safety collaboration with Pfizer
![](/46/pdcnewsitem/03/86/34/hemoshear.png)
Development of a biological and computational model for prediction of drug-induced vascular injury for early-stage compounds.
HemoShear Therapeutics will be initiating the next stage of a multi-year collaboration with Pfizer Inc. Under the terms of the agreement, which combines the scientific and technical expertise of both companies, HemoShear will leverage its proprietary discovery platform, REVEAL-Tx, with the aim of developing a predictive model for preclinical drug-induced vascular injury (DIVI). Financial terms were not disclosed.
The initial stage of the collaboration between HemoShear and Pfizer was designed to assess the repeatability of vascular toxicities of a specifically chosen set of drugs in HemoShear's REVEAL-Tx platform. In this next stage, the companies will use HemoShear's platform to assess a large number of compounds with the aim of building a predictive computational model that would be used for evaluation of vascular safety of Pfizer drug compounds before entering pre-clinical stages of development.
"Drug toxicity discovered in pre-clinical or clinical trials has serious implications for drug development," said Jim Powers, CEO at HemoShear. "Our collaboration has the potential to create a new safety paradigm for the pharmaceutical industry that improves confidence in selecting safer drug candidates for pre-clinical trials, and we look forward to working with Pfizer to further develop this much needed, predictive model."
DIVI poses a safety dilemma for the pharmaceutical industry because of limitations in resolving the underlying drivers of vascular injury. In addition, there are no generally accepted diagnostic or predictive biomarkers to understand when or why DIVI will occur, nor are there models to select the safest compound prior to animal testing. If drug toxicity occurs in an animal, significant program delays and additional costs are incurred to investigate and explain the underlying biology and determine whether the compound is safe to move forward to human testing, or to determine if another compound would be safer. In some cases, decisions are made to stop a program altogether in the absence of a clear understanding of the injury and whether an animal response translates to human clinical outcomes.
In addition to leveraging REVEAL-Tx for safety and drug discovery collaborations with pharmaceutical companies, HemoShear Therapeutics is pursuing its own drug discovery programs in metabolic diseases with high unmet need.
Related News
-
News CPHI Podcast Series: the power of digital marketing in pharma
Digital marketing is a valuable tool for many industries, and the pharmaceutical and healthcare industry is no exception. The CPHI Podcast Series covers how marketing can be used by companies to increase their engagement and overcome challenges.&n... -
News Novel approach to creating sustainable packaging from rice husks
Researchers have created a new approach to the designing of eco-friendly nanofibres extracted from rice husks, addressing the critical need for sustainable packaging materials in food and biopharmaceutical products. -
News BioNTech to begin mRNA vaccine manufacturing in Rwanda by 2025
German biotechnology company BioNTech has stated their intentions to begin production at their mRNA vaccine factory in Rwanda by 2025, which will mark the first foreign mRNA vaccine manufacturing site on the continent of Africa. -
News Identifying Alzheimer’s Disease biomarker proteins with whole blood tests
A University of Manchester spin-out pharmaceutical company, PharmaKure, has reported successful study results for the quantification of Alzheimer’s Disease biomarker proteins with a whole blood test. -
News Bill & Melinda Gates Foundation to boost mRNA vaccine initiatives in Africa with USD $40m
To address vaccine inequality and accessibility issues, the Bill & Melinda Gates Foundation aims to deliver USD $40m to various biotech companies and vaccine manufacturers in support of mRNA vaccine development. -
News CPHI Podcast Series: Exploring neurological frontiers in Alzheimer's and beyond
The next episode of the CPHI Podcast Series delves into the science and background behind some recent developments in the field of Alzheimer's disease and neurological disorders. -
News Is patient centricity the future of pharmaceutical manufacturing?
In this interview with Sandra Sánchez y Oldenhage, President of PharmAdvice, she speaks to the importance of considering patients in the manufacturing stages of the pharmaceutical supply chain, and how it can redefine healthcare. -
News CPHI Podcast Series: How to leverage AI for Drug Discovery
Artificial intelligence is the topic of debate in the latest episode from the CPHI Podcast Series, where Digital Editor Lucy Chard speaks with Bill Whitford of DPS Group about the integration of AI in healthcare.
Position your company at the heart of the global Pharma industry with a CPHI Online membership
-
Your products and solutions visible to thousands of visitors within the largest Pharma marketplace
-
Generate high-quality, engaged leads for your business, all year round
-
Promote your business as the industry’s thought-leader by hosting your reports, brochures and videos within your profile
-
Your company’s profile boosted at all participating CPHI events
-
An easy-to-use platform with a detailed dashboard showing your leads and performance