Genentech Cancer Drug Receives Positive Phase III Study Results
The study showed pertuzumab combined with Herceptin (trastuzumab) and docetaxel chemotherapy improved progression-free survival rate compared to Herceptin and docetaxel in people with metastatic breast cancer.
Roche's US subsidiary Genentech announced its Cleopatra Phase III study of pertuzumab combined with Herceptin plus docetaxel chemotherapy in patients with HER2-positive metastatic breast cancer has met its primary endpoint.
Pertuzumab, a HER2 dimerisation inhibitor, prevents the HER2 receptor from pairing with other HER receptors and blocks cell signalling, which may inhibit cancer cell growth.
Herceptin is not a chemotherapy but a targeted medicine, designed to specifically block the HER2 protein on the surface of some cancer cells.
The randomised, double-blind, placebo-controlled two-arm study enrolled 808 people with previously untreated HER2-positive metastat
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